Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.47 |
| ▸ | GABRE | P78334 | 1/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.47 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26971046 | 0.81 | MAPT (0.48) | MAPTMEN1KMT2AKDM4EPOLB | |
| SCHEMBL2657909 | 0.78 | QPCT (0.56) | MAPTKDM4EPOLBHTTALDH1A1 | |
| SCHEMBL17924368 | 0.78 | MEN1 (0.46) | MAPTMEN1KMT2AKDM4EPOLB | |
| SCHEMBL10162131 | 0.78 | MAPT (0.48) | MAPTMEN1KMT2AKDM4EPOLB | |
| SCHEMBL600130 | 0.77 | MAPT (0.64) | MAPTMEN1KMT2AGABRPGABRD | |
| SCHEMBL2729427 | 0.77 | KCNJ1 (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL28896722 | 0.77 | LMNA (0.62) | MEN1KMT2AGABRPGABRDGABRA1 | |
| SCHEMBL28408444 | 0.75 | EGLN1 (0.47) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10130876 | 0.75 | MAPT (0.42) | MAPTMEN1KMT2AKDM4EPOLB | |
| SCHEMBL28823761 | 0.73 | NAMPT (0.52) | KMT2AGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471923-A4 | AMIDO MACROLIDES | KOSAN BIOSCIENCES INC (US) | 2006-01-11 | — | — | EP | disclosed |
| US-6939861-B2 | Amido macrolides | KOSAN BIOSCIENCES, INC. (US) | 2005-09-06 | — | — | US | disclosed |
| EP-1471923-A1 | AMIDO MACROLIDES | Kosan Biosciences, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| US-20030199458-A1 | Amido macrolides | KOSAN BIOSCIENCES, INC. | 2003-10-23 | — | — | US | disclosed |
| WO-2003061671-A1 | AMIDO MACROLIDES | KOSAN BIOSCIENCES, INC. (US) | 2003-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199458-A1 | Amido macrolides | PCSK9, ABCB4, PCSK7 | MAPT 4657/4885MEN1 2706/4885KMT2A 4559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.