Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 2/20 | 0.49 |
| ▸ | CDC7 | O00311 | 4/20 | 0.48 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7063637 | 0.84 | KDM4E (0.76) | KDM4EALDH1A1KMT2AGAALMNA | |
| SCHEMBL4794758 | 0.81 | CDC7 (0.50) | KDM4EALDH1A1KMT2ALMNAIKBKB | |
| SCHEMBL7457367 | 0.78 | KDM4E (0.68) | KDM4EALDH1A1KMT2AGAALMNA | |
| SCHEMBL1705162 | 0.77 | CDC7 (0.59) | KDM4EALDH1A1KMT2ALMNAIKBKB | |
| SCHEMBL5669674 | 0.76 | TGFBR1 (0.50) | KDM4EALDH1A1KMT2AGAAIKBKB | |
| SCHEMBL28814328 | 0.76 | IDO1 (0.56) | KDM4EALDH1A1KMT2AGAALMNA | |
| SCHEMBL29783027 | 0.73 | ALDH1A1 (1.00) | KDM4EALDH1A1KMT2AGAALMNA | |
| SCHEMBL14801199 | 0.73 | KDM4E (0.57) | KDM4EALDH1A1KMT2AGAALMNA | |
| SCHEMBL596082 | 0.73 | KDM4E (1.00) | KDM4EALDH1A1KMT2AGAALMNA | |
| SCHEMBL1574901 | 0.73 | ALDH1A1 (1.00) | KDM4EALDH1A1KMT2AGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1610780-A4 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2006-05-03 | — | — | EP | disclosed |
| EP-1610780-A2 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004085388-A2 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-10-07 | — | — | WO | disclosed |