Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.53 |
| ▸ | SLC40A1 | Q9NP59 | 11/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5667932 | 0.80 | SLC40A1 (0.46) | IGF1RSLC40A1HIF1ANPC1RAB9A | |
| SCHEMBL5667924 | 0.80 | SLC40A1 (0.46) | IGF1RSLC40A1HIF1ANPC1RAB9A | |
| SCHEMBL2187599 | 0.80 | HIF1A (0.55) | IGF1RSLC40A1HIF1ANPC1RAB9A | |
| SCHEMBL2172176 | 0.78 | HDAC3 (0.51) | IGF1RSLC40A1HIF1ANPC1RAB9A | |
| SCHEMBL4550570 | 0.78 | SLC40A1 (0.52) | IGF1RSLC40A1HIF1ANPC1RAB9A | |
| SCHEMBL2172634 | 0.78 | TRPV1 (0.56) | IGF1RSLC40A1HIF1ANPC1RAB9A | |
| SCHEMBL5668846 | 0.77 | IGF1R (0.47) | IGF1RSLC40A1HIF1ARAB9AMEN1 | |
| SCHEMBL5668071 | 0.77 | IGF1R (0.48) | IGF1RSLC40A1HIF1ANPC1RAB9A | |
| SCHEMBL2174499 | 0.76 | CNR1 (0.49) | IGF1RSLC40A1HIF1ANPC1RAB9A | |
| SCHEMBL4395207 | 0.75 | CNR1 (0.51) | IGF1RSLC40A1HIF1ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730128-A1 | ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005097765-A1 | ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-10-20 | — | — | WO | disclosed |