Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4395207 | 0.88 | CNR1 (0.51) | CNR1SLC40A1IGF1RRAB9AHIF1A | |
| SCHEMBL2172958 | 0.81 | CNR1 (0.54) | CNR1IGF1RRAB9AHIF1AGAA | |
| SCHEMBL5669690 | 0.81 | MAPT (0.65) | RAB9AHIF1AGAANPC1NAMPT | |
| SCHEMBL4384669 | 0.78 | RAB9A (0.53) | RAB9AGAANPC1L3MBTL1NAMPT | |
| SCHEMBL5668071 | 0.78 | IGF1R (0.48) | SLC40A1IGF1RRAB9AHIF1ANPC1 | |
| SCHEMBL2172176 | 0.77 | HDAC3 (0.51) | SLC40A1IGF1RRAB9AHIF1ANPC1 | |
| SCHEMBL2187599 | 0.77 | HIF1A (0.55) | SLC40A1IGF1RRAB9AHIF1ANPC1 | |
| SCHEMBL5669757 | 0.76 | IGF1R (0.53) | SLC40A1IGF1RRAB9AHIF1ANPC1 | |
| SCHEMBL4550570 | 0.76 | SLC40A1 (0.52) | SLC40A1IGF1RRAB9AHIF1ANPC1 | |
| SCHEMBL5667924 | 0.73 | SLC40A1 (0.46) | SLC40A1IGF1RRAB9AHIF1ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973061-B2 | Anaplastic lymphoma kinase modulators and methods of use | EXELIXIS, INC. (US) | 2011-07-05 | — | — | US | disclosed |