SCHEMBL5670176

SCHEMBL5670176

COP(=O)(OC)C(C)(C)C(=O)C=Cc1cc(C2CCCC2)c(O)c(C2CCCC2)c1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.33
CYP3A4 P08684 2/20 0.33
CYP2D6 P10635 2/20 0.33
CYP2C9 P11712 2/20 0.33
CYP2B6 P20813 2/20 0.33
KMT2A Q03164 4/20 0.33
KDM4E B2RXH2 2/20 0.33
MEN1 O00255 2/20 0.33
MAPT P10636 1/20 0.33
PKM P14618 1/20 0.33
PTGS1 P23219 1/20 0.33
PTGS2 P35354 1/20 0.33
MET P08581 2/20 0.32
BACE1 P56817 1/20 0.32
GABBR2 O75899 1/20 0.32
GABBR1 Q9UBS5 1/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.31
ALOX5 P09917 2/20 0.31
NFKB1 P19838 1/20 0.30
STAT3 P40763 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5670173 1.00 CYP1A2 (0.33) CYP1A2CYP3A4CYP2D6CYP2C9CYP2B6
SCHEMBL5664312 0.86 PTPN5 (0.35) CYP1A2CYP3A4CYP2D6CYP2C9CYP2B6
SCHEMBL6685969 0.86 PTPN5 (0.35) CYP1A2CYP3A4CYP2D6CYP2C9CYP2B6
SCHEMBL7065924 0.78 CYP1A2 (0.53) CYP1A2CYP3A4CYP2D6CYP2C9CYP2B6
SCHEMBL7065928 0.78 CYP1A2 (0.53) CYP1A2CYP3A4CYP2D6CYP2C9CYP2B6
SCHEMBL6916852 0.77 GABBR2 (0.55) CYP1A2CYP2C9PTGS1PTGS2GABBR2
SCHEMBL5668055 0.77 CYP1A2 (0.59) CYP1A2CYP3A4CYP2D6CYP2C9CYP2B6
SCHEMBL5668058 0.77 CYP1A2 (0.59) CYP1A2CYP3A4CYP2D6CYP2C9CYP2B6
SCHEMBL7065917 0.75 CYP1A2 (0.40) CYP1A2CYP3A4CYP2D6CYP2C9CYP2B6
SCHEMBL7065918 0.75 CYP1A2 (0.40) CYP1A2CYP3A4CYP2D6CYP2C9CYP2B6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1551418-A4 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY ILEX ONCOLOGY RES SARL (CH) 2006-05-03 EP disclosed
EP-1551418-A1 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY Ilex Oncology Research Sàrl (CH) 2005-07-13 EP disclosed
WO-2004026315-A1 SUBSTITUTED KETOPHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO disclosed
WO-2004026242-A2 SUBSTITUTED KETOPHOSPHONATE INHIBITORS OF TUMOR CELL PROLIFERATION ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO disclosed