Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 8/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.42 |
| ▸ | JAK2 | O60674 | 6/20 | 0.42 |
| ▸ | JAK3 | P52333 | 4/20 | 0.41 |
| ▸ | CASP3 | P42574 | 3/20 | 0.40 |
| ▸ | CASP7 | P55210 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.39 |
| ▸ | CHUK | O15111 | 2/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.37 |
| ▸ | PRKCG | P05129 | 2/20 | 0.37 |
| ▸ | PRKCB | P05771 | 2/20 | 0.37 |
| ▸ | PRKCA | P17252 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 2/20 | 0.37 |
| ▸ | PRKACG | P22612 | 2/20 | 0.37 |
| ▸ | PRKACB | P22694 | 2/20 | 0.37 |
| ▸ | PRKCH | P24723 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL567071 | 1.00 | ROCK1 (0.42) | ROCK1ROCK2JAK2JAK3CASP3 | |
| Hydrochloric Acid SCHEMBL567136 | 0.99 | ROCK1 (0.41) | ROCK1ROCK2JAK2JAK3CASP3 | |
| Hydrochloric Acid SCHEMBL567137 | 0.99 | ROCK1 (0.41) | ROCK1ROCK2JAK2JAK3CASP3 | |
| SCHEMBL567620 | 0.97 | ROCK1 (0.42) | ROCK1ROCK2JAK2JAK3CASP3 | |
| SCHEMBL567619 | 0.97 | ROCK1 (0.42) | ROCK1ROCK2JAK2JAK3CASP3 | |
| Hydrochloric Acid SCHEMBL567761 | 0.96 | ROCK1 (0.42) | ROCK1ROCK2JAK2JAK3CASP3 | |
| Hydrochloric Acid SCHEMBL567760 | 0.96 | ROCK1 (0.42) | ROCK1ROCK2JAK2JAK3CASP3 | |
| SCHEMBL567948 | 0.90 | POLB (0.49) | ROCK1ROCK2JAK2JAK3CASP3 | |
| SCHEMBL567947 | 0.90 | POLB (0.49) | ROCK1ROCK2JAK2JAK3CASP3 | |
| Hydrochloric Acid SCHEMBL567663 | 0.89 | POLB (0.48) | ROCK1ROCK2JAK2JAK3CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444395-B1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | WESTERN THERAPEUTICS INST INC D (JP) | 2016-01-06 | — | — | EP | claimed |
| EP-2444395-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. Western Therapeutics Institute, Inc. (JP) | 2012-04-25 | — | — | EP | claimed |
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. WESTERN THERAPEUTICS INSTITUTE, INC (JP) | 2012-02-09 | — | — | US | claimed |
| EP-2444395-B1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | WESTERN THERAPEUTICS INST INC D (JP) | 2016-01-06 | — | — | EP | disclosed |
| US-8951997-B2 | Substituted isoquinoline derivative | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2015-02-10 | — | — | US | disclosed |
| EP-2444395-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. Western Therapeutics Institute, Inc. (JP) | 2012-04-25 | — | — | EP | disclosed |
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. WESTERN THERAPEUTICS INSTITUTE, INC (JP) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | SULT1A1, SULT1E1, SULT2A1 | ROCK1 1837/4885ROCK2 1689/4885JAK2 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.