Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5671832 | 0.83 | AKR1C3 (0.48) | LMNAAKR1C3AKR1C2L3MBTL1MAPT | |
| SCHEMBL28261500 | 0.77 | TSHR (0.41) | LMNAL3MBTL1MAPTKDM4EALDH1A1 | |
| SCHEMBL12117477 | 0.74 | CYP3A4 (0.54) | LMNAL3MBTL1MAPTKDM4EALDH1A1 | |
| SCHEMBL30443001 | 0.74 | CYP3A4 (0.54) | LMNAL3MBTL1MAPTKDM4EALDH1A1 | |
| SCHEMBL17077864 | 0.74 | TSHR (0.39) | LMNAL3MBTL1ALDH1A1KMT2AMEN1 | |
| SCHEMBL17846074 | 0.73 | TDP1 (0.40) | LMNAMAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL16113033 | 0.73 | ALDH1A1 (0.38) | LMNAL3MBTL1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL4841484 | 0.73 | KMT2A (0.43) | LMNAMAPTSMN1; SMN2HTTPOLB | |
| SCHEMBL7375645 | 0.72 | TSHR (0.37) | LMNAL3MBTL1MAPTKDM4EALDH1A1 | |
| SCHEMBL729160 | 0.72 | ITGA4 (0.40) | MAPTSMN1; SMN2PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660467-A2 | AMINOFURAZAN COMPOUNDS AS PROTEIN KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019190-A2 | (4 -AMINO -1,2, 5-OXADIAZOL-4-YL) -HETΞROAROMATIC COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-03-03 | — | — | WO | disclosed |