Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 13/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5670025 | 0.91 | F10 (0.53) | F10F2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5565655 | 0.87 | F10 (0.39) | F10SLC6A2SLC6A4SLC6A3CNR1 | |
| SCHEMBL5669932 | 0.83 | F10 (0.57) | F10F2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5570583 | 0.83 | CNR1 (0.50) | CNR1EP300 | |
| SCHEMBL5672325 | 0.81 | F10 (0.56) | F10F2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5570728 | 0.79 | ALDH1A1 (0.41) | CNR1ALDH1A1RORC | |
| SCHEMBL5570803 | 0.78 | F10 (0.40) | F10SLC6A2SLC6A4SLC6A3CNR1 | |
| SCHEMBL5672305 | 0.78 | F10 (0.59) | F10F2KDM4EALDH1A1 | |
| SCHEMBL5671101 | 0.74 | F10 (0.54) | F10RORC | |
| SCHEMBL5565671 | 0.73 | CNR1 (0.43) | F10SLC6A2SLC6A4SLC6A3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628668-A2 | 1,1-DISUBSTITUTEDCYCLOALKYL-, GLYCINAMIDYL-, SULFONYL-AMIDINO-, AND TETRAHYDROPYRIMIDINYL-CONTAINING DIAMINOALKYL, BETA-AMINOACIDS, ALPHA-AMINOACIDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITO RS | Bristol-Myers Squibb Company (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004108892-A2 | 1,1-DISUBSTITUTEDCYCLOALKYL-, GLYCINAMIDYL-, SULFONYL-AMIDINO-, AND TETRAHYDROPYRIMIDINYL-CONTAINING DIAMINOALKYL, β-AMINOACIDS, α-AMINOACIDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-16 | — | — | WO | disclosed |