Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 9/20 | 0.54 |
| ▸ | RORC | P51449 | 4/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PROC | P04070 | 1/20 | 0.42 |
| ▸ | HPN | P05981 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | RORA | P35398 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5672580 | 0.80 | F10 (0.56) | F10RORC | |
| SCHEMBL5670025 | 0.76 | F10 (0.53) | F10 | |
| SCHEMBL4741434 | 0.75 | F10 (0.69) | F10 | |
| SCHEMBL5570331 | 0.75 | RORA (0.49) | RORCHPNPLAURORA | |
| SCHEMBL5672305 | 0.74 | F10 (0.59) | F10 | |
| SCHEMBL5670815 | 0.74 | F10 (0.52) | F10RORC | |
| SCHEMBL5670109 | 0.73 | F10 (0.61) | F10 | |
| SCHEMBL3429658 | 0.73 | F10 (0.50) | F10HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL3429653 | 0.73 | F10 (0.50) | F10HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL3028095 | 0.73 | F10 (0.57) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628668-A2 | 1,1-DISUBSTITUTEDCYCLOALKYL-, GLYCINAMIDYL-, SULFONYL-AMIDINO-, AND TETRAHYDROPYRIMIDINYL-CONTAINING DIAMINOALKYL, BETA-AMINOACIDS, ALPHA-AMINOACIDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITO RS | Bristol-Myers Squibb Company (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004108892-A2 | 1,1-DISUBSTITUTEDCYCLOALKYL-, GLYCINAMIDYL-, SULFONYL-AMIDINO-, AND TETRAHYDROPYRIMIDINYL-CONTAINING DIAMINOALKYL, β-AMINOACIDS, α-AMINOACIDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-12-16 | — | — | WO | disclosed |