Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5671296 | 1.00 | MAPT (0.44) | MAPTALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL11114740 | 0.80 | TRPA1 (0.48) | MAPTALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL11114722 | 0.80 | TRPA1 (0.48) | MAPTALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL31147724 | 0.78 | CYP11B1 (0.43) | MAPTALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL4711544 | 0.76 | MAPT (0.49) | MAPTALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL4711270 | 0.76 | MAPT (0.49) | MAPTALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL5671298 | 0.74 | ALDH1A1 (0.45) | MAPTALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL19620498 | 0.74 | LRRK2 (0.39) | MAPTALDH1A1KDM4EHPGDKMT2A | |
| Water SCHEMBL22130353 | 0.72 | ALDH1A1 (0.59) | MAPTALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL27482209 | 0.72 | MAPT (0.54) | MAPTALDH1A1KDM4EHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729771-A1 | PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS | Eli Lilly & Company (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005094822-A1 | PYRIDYL DERIVATIVES AND THEIR USE AS MGLU5 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2005-10-13 | — | — | WO | disclosed |