Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH5 | Q6P6C2 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | HTT | P42858 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.51 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11755279 | 0.84 | MAPT (0.65) | ALKBH5MEN1KMT2AMAPTLMNA | |
| SCHEMBL2085581 | 0.82 | MAPT (0.69) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL5673458 | 0.82 | ALKBH5 (0.61) | ALKBH5MEN1KMT2AMAPTLMNA | |
| SCHEMBL23400261 | 0.78 | NOX4 (0.54) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL1414675 | 0.78 | MAPT (0.65) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL23400761 | 0.78 | MAPT (0.57) | ALKBH5MEN1KMT2AMAPTLMNA | |
| SCHEMBL407942 | 0.77 | ALKBH5 (0.64) | ALKBH5MEN1KMT2AMAPTLMNA | |
| SCHEMBL9808001 | 0.77 | MEN1 (0.56) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL11756851 | 0.76 | KMT2A (0.55) | ALKBH5MEN1KMT2AMAPTLMNA | |
| SCHEMBL23398682 | 0.76 | MAPT (0.55) | ALKBH5MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1213965-B1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2006-01-18 | — | — | EP | disclosed |
| US-6670387-B1 | Thrombocytopenia; hydroxy-1-azo-naphthalene derivatives; 3-hydroxy-4-((2-hydroxy-1-naphthalenyl)azo-)-1-naphthalenesul fonic acid; promoters of thrombopoiesis and megakaryocytopoi esis; enhancing platelet production; agonizing TPO receptor | SMITHKLINE BEECHAM CORPORATION | 2003-12-30 | — | — | US | disclosed |
| US-6642265-B1 | Treating thrombocytopenia, in a mammal, including a human, by administering a hydroxy-1-azobenzene derivative | SMITHKLINE BEECHAM CORPORATION | 2003-11-04 | — | — | US | disclosed |
| EP-1213965-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-1156804-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1213965-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-06-19 | — | — | EP | disclosed |
| EP-1156804-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-11-28 | — | — | EP | disclosed |
| WO-2001017349-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BECKMAN CORPORATION (US) | 2001-03-15 | — | — | WO | disclosed |
| WO-2000035446-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |