Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 2/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2733410 | 0.83 | KIF11 (0.68) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL7675386 | 0.80 | KMO (0.55) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL20089424 | 0.80 | KIF11 (0.64) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL10940225 | 0.76 | NPY5R (0.64) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL3655647 | 0.75 | NPY5R (0.43) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL12103445 | 0.74 | CYP2A6 (0.79) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL30620885 | 0.74 | CYP2A6 (0.79) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL17951830 | 0.74 | CYP2A6 (0.79) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL13179001 | 0.74 | KIF11 (0.70) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL4502483 | 0.73 | KIF11 (0.73) | MKNK1MKNK2KIF11CYP2A6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581510-A4 | 1-ARYL-2-HYDROXYETHYL AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL MYERS SQUIBB CO (US) | 2006-08-30 | — | — | EP | disclosed |
| EP-1581510-A2 | 1-ARYL-2-HYDROXYETHYL AMIDES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004047743-A2 | 1-ARYL-2-HYDROXYETHYL AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |