Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | ERN1 | O75460 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913390 | 0.86 | ALDH1A1 (0.68) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL29409289 | 0.84 | MAPT (1.00) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL737722 | 0.84 | MAPT (1.00) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL5952772 | 0.81 | TDP1 (0.79) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL3178960 | 0.81 | MAPT (0.85) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL30581227 | 0.81 | MAPT (0.85) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL10714493 | 0.81 | TDP1 (0.85) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL9649469 | 0.81 | TDP1 (0.85) | TDP1MAPTMEN1POLBKMT2A | |
| Hydrochloric Acid SCHEMBL3973011 | 0.81 | MAPT (0.92) | TDP1MAPTMEN1POLBKMT2A | |
| Hydrochloric Acid SCHEMBL3973012 | 0.81 | MAPT (0.92) | TDP1MAPTMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135493-B2 | HDAC inhibitor | ASTELLAS PHARMA INC. (JP) | 2006-11-14 | — | — | US | disclosed |
| US-20040229889-A1 | HDAC inhibitor | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-18 | — | — | US | disclosed |
| WO-2004063169-A1 | HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229889-A1 | HDAC inhibitor | HDAC1, HDAC2, HDAC11 | TDP1 2228/4885MAPT 3618/4885MEN1 2199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.