Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 11/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | PRKACA | P17612 | 5/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.44 |
| ▸ | PRKACG | P22612 | 4/20 | 0.44 |
| ▸ | PRKACB | P22694 | 4/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.44 |
| ▸ | AKT1 | P31749 | 3/20 | 0.44 |
| ▸ | PLK4 | O00444 | 2/20 | 0.44 |
| ▸ | MARK3 | P27448 | 2/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.44 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL566186 | 1.00 | ROCK1 (0.47) | ROCK1ROCK2JAK2PRKACAPRKCD | |
| SCHEMBL566187 | 1.00 | ROCK1 (0.47) | ROCK1ROCK2JAK2PRKACAPRKCD | |
| Hydrochloric Acid SCHEMBL566206 | 0.99 | ROCK1 (0.46) | ROCK1ROCK2JAK2PRKACAPRKCD | |
| Hydrochloric Acid SCHEMBL568193 | 0.99 | ROCK1 (0.46) | ROCK1ROCK2JAK2PRKACAPRKCD | |
| Hydrochloric Acid SCHEMBL566207 | 0.99 | ROCK1 (0.46) | ROCK1ROCK2JAK2PRKACAPRKCD | |
| SCHEMBL566976 | 0.93 | ROCK1 (0.53) | ROCK1ROCK2JAK2PRKACAPRKCD | |
| SCHEMBL567167 | 0.93 | ROCK1 (0.53) | ROCK1ROCK2JAK2PRKACAPRKCD | |
| SCHEMBL566975 | 0.93 | ROCK1 (0.53) | ROCK1ROCK2JAK2PRKACAPRKCD | |
| Hydrochloric Acid SCHEMBL567794 | 0.92 | ROCK1 (0.53) | ROCK1ROCK2JAK2PRKACAPRKCD | |
| Hydrochloric Acid SCHEMBL567209 | 0.92 | ROCK1 (0.53) | ROCK1ROCK2JAK2PRKACAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2444395-B1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | WESTERN THERAPEUTICS INST INC D (JP) | 2016-01-06 | — | — | EP | claimed |
| US-8951997-B2 | Substituted isoquinoline derivative | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2015-02-10 | — | — | US | claimed |
| EP-2444395-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. Western Therapeutics Institute, Inc. (JP) | 2012-04-25 | — | — | EP | claimed |
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. WESTERN THERAPEUTICS INSTITUTE, INC (JP) | 2012-02-09 | — | — | US | claimed |
| EP-2444395-B1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | WESTERN THERAPEUTICS INST INC D (JP) | 2016-01-06 | — | — | EP | disclosed |
| EP-2444395-B1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | WESTERN THERAPEUTICS INST INC D (JP) | 2016-01-06 | — | — | EP | disclosed |
| US-8951997-B2 | Substituted isoquinoline derivative | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2015-02-10 | — | — | US | disclosed |
| US-8951997-B2 | Substituted isoquinoline derivative | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2015-02-10 | — | — | US | disclosed |
| EP-2444395-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. Western Therapeutics Institute, Inc. (JP) | 2012-04-25 | — | — | EP | disclosed |
| EP-2444395-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. Western Therapeutics Institute, Inc. (JP) | 2012-04-25 | — | — | EP | disclosed |
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. WESTERN THERAPEUTICS INSTITUTE, INC (JP) | 2012-02-09 | — | — | US | disclosed |
| WO-2010146881-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | 株式会社デ・ウエスタン・セラピテクス研究所 (JP) | 2010-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | SULT1A1, SULT1E1, SULT2A1 | ROCK1 1837/4885ROCK2 1689/4885JAK2 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.