Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 20/20 | 0.48 |
| ▸ | CTRC | Q99895 | 3/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5672979 | 0.89 | F2 (0.46) | F2CTRCPRSS2 | |
| SCHEMBL5674293 | 0.87 | F2 (0.58) | F2CTRC | |
| SCHEMBL5673352 | 0.85 | ALPL (0.48) | F2CTRC | |
| SCHEMBL5676099 | 0.85 | F2 (0.57) | F2CTRCPRSS2 | |
| SCHEMBL5672878 | 0.84 | F2 (0.49) | F2CTRCPRSS2 | |
| SCHEMBL5675805 | 0.82 | F2 (0.68) | F2CTRCPRSS2 | |
| SCHEMBL5673452 | 0.81 | F2 (0.69) | F2CTRCPRSS2 | |
| SCHEMBL5675835 | 0.80 | F2 (0.68) | F2CTRC | |
| SCHEMBL5672782 | 0.80 | F2 (0.70) | F2CTRCPRSS2 | |
| SCHEMBL5672986 | 0.80 | F2 (0.59) | F2CTRCPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906091-B1 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-10-04 | — | — | EP | disclosed |
| EP-0906091-A4 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-0906091-A1 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| US-5891909-A | Amidinohydrazones as protease inhibitors | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997036580-A1 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1997-10-09 | — | — | WO | disclosed |