Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 9/20 | 0.56 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.49 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.49 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928521 | 0.84 | AR (0.55) | ARF2 | |
| SCHEMBL8548528 | 0.80 | F2 (0.72) | SLC22A12CYP2C9SLC22A6SLC22A8SLC22A11 | |
| SCHEMBL5673572 | 0.78 | PTGDR2 (0.46) | SLC22A12PTGDR2 | |
| SCHEMBL8547066 | 0.78 | SLC22A12 (0.53) | SLC22A12F2 | |
| SCHEMBL8483951 | 0.77 | PTGDR2 (0.44) | SLC22A12PTGDR2F2 | |
| SCHEMBL8483944 | 0.77 | PTGDR2 (0.42) | SLC22A12PTGDR2F2 | |
| SCHEMBL20627706 | 0.73 | PTGDR2 (0.63) | SLC22A12PTGDR2CYP2C9SLC22A6SLC22A8 | |
| SCHEMBL3769130 | 0.72 | SLC22A12 (0.70) | SLC22A12CYP2C9SLC22A6SLC22A8SLC22A11 | |
| SCHEMBL7419857 | 0.72 | GRM5 (0.51) | ARF2 | |
| SCHEMBL5676397 | 0.72 | MGLL (0.39) | PTGDR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906091-B1 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-10-04 | — | — | EP | disclosed |
| EP-0906091-A4 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-0906091-A1 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| US-5891909-A | Amidinohydrazones as protease inhibitors | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1997036580-A1 | AMIDINOHYDRAZONES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 1997-10-09 | — | — | WO | disclosed |