Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5673468 | 1.00 | ALDH1A1 (0.43) | ALDH1A1POLBMEN1KMT2AKDM4E | |
| SCHEMBL5675277 | 0.92 | HTT (0.43) | ALDH1A1POLBMEN1KMT2AKDM4E | |
| SCHEMBL5675192 | 0.92 | HTT (0.43) | ALDH1A1POLBMEN1KMT2AKDM4E | |
| SCHEMBL5675278 | 0.91 | MEN1 (0.45) | ALDH1A1POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL5675286 | 0.91 | MEN1 (0.45) | ALDH1A1POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL5672423 | 0.90 | SMN1; SMN2 (0.40) | POLBMEN1KMT2AHTTTDP1 | |
| SCHEMBL5672401 | 0.89 | TEAD1 (0.41) | POLBMEN1KMT2AKDM4EHTT | |
| SCHEMBL5672403 | 0.89 | TEAD1 (0.41) | POLBMEN1KMT2AKDM4EHTT | |
| SCHEMBL5672426 | 0.89 | LMNA (0.42) | ALDH1A1POLBMEN1KMT2AL3MBTL1 | |
| SCHEMBL5672419 | 0.89 | LMNA (0.42) | ALDH1A1POLBMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1213965-B1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2006-01-18 | — | — | EP | claimed |
| US-6642265-B1 | Treating thrombocytopenia, in a mammal, including a human, by administering a hydroxy-1-azobenzene derivative | SMITHKLINE BEECHAM CORPORATION | 2003-11-04 | — | — | US | claimed |
| EP-1213965-B1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2006-01-18 | — | — | EP | disclosed |
| US-6642265-B1 | Treating thrombocytopenia, in a mammal, including a human, by administering a hydroxy-1-azobenzene derivative | SMITHKLINE BEECHAM CORPORATION | 2003-11-04 | — | — | US | disclosed |