Threonine

Threonine

SCHEMBL567434

C[C@@H](O)[C@H](N)C(=O)O.c1ccc2c(c1)C2

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.42
SLC1A2 P43004 7/20 0.41
SLC1A3 P43003 6/20 0.41
SLC1A1 P43005 6/20 0.41
DPP8 Q6V1X1 2/20 0.41
DPP9 Q86TI2 2/20 0.41
DPP7 Q9UHL4 2/20 0.41
DPP4 P27487 1/20 0.41
SLC7A5 Q01650 1/20 0.40
TARS1 P26639 1/20 0.38
LMNA P02545 2/20 0.38
ADRA2A P08913 1/20 0.38
ADRA2C P18825 1/20 0.38
HIF1A Q16665 1/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Threonine SCHEMBL10663811 1.00 HTR2A (0.42) HTR2ASLC1A2SLC1A3SLC1A1DPP8
Threonine SCHEMBL562233 1.00 HTR2A (0.42) HTR2ASLC1A2SLC1A3SLC1A1DPP8
Threonine SCHEMBL7322815 0.88 SLC1A3 (0.37) HTR2ASLC1A2SLC1A3SLC1A1DPP8
Alanine SCHEMBL16899299 0.82 HTR2A (0.46) HTR2ASLC1A2SLC1A3SLC1A1DPP8
Threonine SCHEMBL2895194 0.82 SLC7A5 (0.57) SLC1A2SLC1A3SLC1A1SLC7A5TARS1
Benzoic Acid SCHEMBL28091621 0.79 TSHR (0.54) SLC1A2SLC1A3SLC1A1SLC7A5LMNA
Threonine SCHEMBL3448821 0.78 AKR1B1 (0.43) SLC1A2SLC1A3SLC1A1SLC7A5TARS1
Threonine SCHEMBL27615994 0.78 SLC7A5 (0.52) SLC1A2SLC1A3SLC1A1SLC7A5TARS1
Threonine SCHEMBL92730 0.77
Threonine SCHEMBL18050155 0.77 SLC7A5 (0.63) SLC1A2SLC1A3SLC1A1SLC7A5ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114324703-B Method for simultaneously detecting multiple amino acids 杭州朱养心药业有限公司 2022-08-30 CN claimed
CN-114324703-A Method for simultaneously detecting multiple amino acids 杭州朱养心药业有限公司 2022-04-12 CN claimed
CN-113788877-A Novel insect kinin analogs and application thereof in aphid control 中国农业大学 2021-12-14 CN claimed
CN-102503850-A Hydroxyl-contained N-acylamino acid and preparation method thereof UNIV TIANJIN 2012-06-20 CN claimed
CN-113788877-B Novel insect kinin analogues and application thereof in aphid control 中国农业大学 2023-11-21 CN disclosed
US-11632948-B2 Recrystallization inhibitor THE UNIVERSITY OF WARWICK (GB) 2023-04-25 US disclosed
CN-114324703-B Method for simultaneously detecting multiple amino acids 杭州朱养心药业有限公司 2022-08-30 CN disclosed
CN-114324703-A Method for simultaneously detecting multiple amino acids 杭州朱养心药业有限公司 2022-04-12 CN disclosed
CN-113788877-A Novel insect kinin analogs and application thereof in aphid control 中国农业大学 2021-12-14 CN disclosed
US-20200178517-A1 RECRYSTALLIZATION INHIBITOR THE UNIVERSITY OF WARWICK (GB) 2020-06-11 US disclosed
EP-3634126-A1 RECRYSTALLIZATION INHIBITOR The University Of Warwick (GB) 2020-04-15 EP disclosed
WO-2018224816-A1 RECRYSTALLIZATION INHIBITOR THE UNIVERSITY OF WARWICK (GB) 2018-12-13 WO disclosed
EP-0272671-A2 Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors SANDOZ LTD. (CH) 1988-06-29 EP disclosed
US-4745124-A THIO/ESTER PEPTIDES UNIVERSITY OF MIAMI (US) 1988-05-17 US disclosed
US-4690936-A AMINO ACIDS, THIOESTER LINKAGE; ANGIOTENSIN INHIBITORS UNIVERSITY OF MIAMI (US) 1987-09-01 US disclosed
EP-0036713-B1 ANGIOTENSIN CONVERTING ENZYME INHIBITORS UNIVERSITY OF MIAMI (US) 1984-01-18 EP disclosed
US-4060689-A Vinylbenzyl esters of n-boc-amino acids MORTON-NORWICH PRODUCTS, INC. (US) 1977-11-29 US disclosed
US-4051171-A Vinylbenzyl esters of N-BOC-amino acids MORTON-NORWICH PRODUCTS, INC. (US) 1977-09-27 US disclosed
US-4033998-A Vinylbenzyl ester of an N-BOC amino acid MORTON-NORWICH PRODUCTS, INC. (US) 1977-07-05 US disclosed
US-4022760-A HORMONES PARKE, DAVIS & COMPANY (US) 1977-05-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200178517-A1 RECRYSTALLIZATION INHIBITOR NOTUM, PPIF, FKBP5 HTR2A 3638/4885SLC1A2 1348/4885SLC1A3 1538/4885
US-11632948-B2 Recrystallization inhibitor NOTUM, PPIF, FKBP5 HTR2A 3638/4885SLC1A2 1348/4885SLC1A3 1538/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.