PPIF — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL12994801	0.79	2/20
SCHEMBL12994808	0.79	2/20
SCHEMBL12994814	0.79	2/20
SCHEMBL1708953	0.78	2/20
SCHEMBL12994815	0.78	2/20
SCHEMBL12994807	0.75	2/20
SCHEMBL1708944	0.72	2/20
SCHEMBL1708965	0.71	2/20
SCHEMBL1708969	0.71	2/20
SCHEMBL1708994	0.69	2/20
SCHEMBL12994810	0.69	2/20
SCHEMBL1708946	0.67	2/20
SCHEMBL9125073	0.54	2/20
SCHEMBL12958868	0.53	2/20
SCHEMBL9124509	0.53	2/20
SCHEMBL9126946	0.53	2/20
SCHEMBL9880086	0.51	2/20
SCHEMBL9125484	0.51	2/20
SCHEMBL9124032	0.49	2/20
SCHEMBL9125077	0.48	2/20

Clinical trials — most relevant to PPIF by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R	PHASE4	WITHDRAWN
Cardioprotective Empagliflozin for Cancer Patients Receiving Doxorubicin	PHASE2/PHASE3	UNKNOWN
The KHENERGY Study	PHASE2	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)	EARLY_PHASE1	COMPLETED
The Effects of Pulsed Electromagnetic Field Therapy on Patients With End-stage of Knee Osteoarthritis	nan	ACTIVE_NOT_RECRUITING
Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC))	nan	COMPLETED
Cardiac Mitochondrial Function in Explanted Human Hearts	nan	UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Ccf mtDNA as a Neurodegenerative Biomarker	nan	UNKNOWN
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Revitalize Cognition: Near Infrared Stimulation in Parkinson Patients	nan	COMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort	nan	RECRUITING
Effect of Branched Chain Amino Acids on Muscle	nan	COMPLETED
Skeletal Muscle Regeneration in Survivors of Critical Illness: How to Prevent Satellite Cell Failure?	nan	RECRUITING
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Diagnostic Odyssey Survey 2	nan	COMPLETED
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome	nan	COMPLETED
Immunometabolism of Machine Perfusion Strategies	nan	RECRUITING
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
Mitochondrial Substrate Utilization in the Diabetic Human Heart	nan	RECRUITING
Collection of Blood and Skin Samples From Patients With Primary Mitochondrial Diseases and Healthy Volunteers	nan	RECRUITING
Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)	nan	RECRUITING
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
Mitochondrial Dysfunction in Diabetes	nan	COMPLETED
Human Mitochondrial Stress-driven Obesity Resistance	nan	COMPLETED
Mitochondrial Oxygen Measurement Variability in Critically Ill Patients (INOX Variability Study)	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a PPIF binder may also engage these)

Protein	Name	Similarity
P29117	—	1.000	P29117 →
P30404	—	1.000	P30404 →
Q99KR7	—	0.997	Q99KR7 →
P52009	—	0.993	P52009 →
Q9SP02	—	0.990	Q9SP02 →
Q0P5D0	—	0.990	Q0P5D0 →
P0C1H9	—	0.989	P0C1H9 →
Q9ZVJ4	—	0.988	Q9ZVJ4 →
Q38900	—	0.988	Q38900 →
PPIH	Peptidyl-prolyl cis-trans isomerase H	0.987	landscape →
Q8X166	—	0.987	Q8X166 →
P54985	—	0.987	P54985 →
P0C1I8	—	0.987	P0C1I8 →
Q8W171	—	0.987	Q8W171 →
Q0ZQK3	—	0.987	Q0ZQK3 →
P0CP83	—	0.986	P0CP83 →
P0CP82	—	0.986	P0CP82 →
P35627	—	0.986	P35627 →
P0C1I0	—	0.986	P0C1I0 →
P52015	—	0.986	P52015 →
P14851	—	0.986	P14851 →
P24368	—	0.986	P24368 →
Q38867	—	0.986	Q38867 →
Q5B4R3	—	0.985	Q5B4R3 →
P24369	—	0.985	P24369 →
P25007	—	0.985	P25007 →
Q8LDP4	—	0.985	Q8LDP4 →
P25719	—	0.985	P25719 →
Q54SM3	—	0.985	Q54SM3 →
P0CP79	—	0.985	P0CP79 →