Sugi Predict

Sugi Predict / Compounds / SCHEMBL5674476

SCHEMBL5674476

SCHEMBL5674476

CCOc1ccccc1C1(CC(=O)N2CCN(c3ccncc3)CC2)C(=O)Nc2ccc(Cl)cc21

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ HTR7 P34969 6/20 0.45
▸ HTR1A P08908 2/20 0.45
▸ SMN1; SMN2 Q16637 2/20 0.44
▸ LMNA P02545 2/20 0.44
▸ TSHR P16473 1/20 0.44
▸ RAB9A P51151 1/20 0.44
▸ NPSR1 Q6W5P4 1/20 0.44
▸ MMP13 P45452 2/20 0.42
▸ ADAM17 P78536 2/20 0.42
▸ ADAMTS5 Q9UNA0 2/20 0.42
▸ MMP2 P08253 1/20 0.40
▸ F10 P00742 2/20 0.39
▸ GRM5 P41594 1/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ CYP3A4 P08684 1/20 0.39
▸ CYP2C9 P11712 1/20 0.39
▸ CYP2C19 P33261 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2499319 0.92 ADAM17 (0.50) HTR7LMNATSHRNPSR1MMP13
SCHEMBL5675399 0.90 ADAMTS5 (0.41) HTR7HTR1ALMNAMMP13ADAM17
SCHEMBL27509614 0.87 F10 (0.40) HTR7HTR1AMMP13ADAM17ADAMTS5
SCHEMBL2492747 0.83 ADAMTS5 (0.50) HTR7TSHRMMP13ADAM17ADAMTS5
SCHEMBL2493671 0.83 KDM4E (0.49) SMN1; SMN2LMNATSHRMMP13ADAM17
SCHEMBL2496303 0.81 KDM4E (0.54) HTR7LMNATSHRNPSR1MMP13
SCHEMBL2494093 0.81 ADAM17 (0.44) LMNATSHRMMP13ADAM17ADAMTS5
SCHEMBL2492641 0.80 TP53 (0.44) LMNAMMP13ADAM17ADAMTS5MMP2
SCHEMBL6599965 0.80 AVPR1B (0.48) LMNARAB9ANPSR1MMP13ADAM17
SCHEMBL2499269 0.79 ADAM17 (0.44) HTR7HTR1ALMNATSHRMMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7119086-B2 Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use SANOFI-AVENTIS (FR) 2006-10-10 — — US disclosed
CN-1224623-C 1-phenylsulfonyl-1, 3-dihydro-2H-indol-2-one derivatives, their preparation and their therapeutic use SANOFI ANWANTE (FR) 2005-10-26 — — CN disclosed
EP-1419150-B1 PHENYLSULFONYL-1,3-DIHYDRO-2H-INDOLE-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE SANOFI AVENTIS (FR) 2005-04-27 — — EP disclosed
CN-1533387-A 1-phenysulfonyl-1,3-dihydro-2H-indole-2-one derivatives, their preparation and their therapeutic use ����ɳŵ��-����������˾ 2004-09-29 — — CN disclosed
US-20040180878-A1 Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use SANOFI-AVENTIS (FR) 2004-09-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040180878-A1 Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use AVPR2, AVPR1A, AVPR1B HTR7 178/4885HTR1A 83/4885SMN1; SMN2 4700/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.