Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.58 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.53 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5859292 | 0.91 | PTGS2 (0.71) | PTGS2PTGS1PDPK1ORAI1CYP1A2 | |
| SCHEMBL5858032 | 0.87 | PTGS2 (0.70) | PTGS2PTGS1PDPK1 | |
| Carbamic Acid SCHEMBL5858404 | 0.87 | PTGS2 (0.57) | PTGS2PTGS1PDPK1 | |
| SCHEMBL5858663 | 0.85 | PTGS2 (0.76) | PTGS2PTGS1PDPK1CYP1A2CYP3A4 | |
| SCHEMBL2695927 | 0.84 | PTGS2 (0.74) | PTGS2PTGS1PDPK1CYP1A2CYP3A4 | |
| SCHEMBL5674417 | 0.83 | PTGS2 (0.70) | PTGS2PTGS1PDPK1HDAC3HDAC4 | |
| SCHEMBL5674345 | 0.83 | PTGS2 (0.83) | PTGS2PTGS1PDPK1CYP2C9 | |
| SCHEMBL14353350 | 0.82 | PTGS2 (0.57) | PTGS2PTGS1PDPK1HDAC3HDAC4 | |
| SCHEMBL5698706 | 0.82 | PTGS2 (0.59) | PTGS2PTGS1PDPK1CYP1A2CYP3A4 | |
| SCHEMBL5674301 | 0.80 | PDPK1 (0.72) | PTGS2PTGS1PDPK1CYP2C9HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060142368-A1 | Compounds and methods for inducing apoptosis in proliferating cells | MRDC | 2006-06-29 | — | — | US | claimed |
| EP-1499597-A4 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | UNIV OHIO STATE RES FOUND (US) | 2006-01-25 | — | — | EP | claimed |
| EP-1499597-A2 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2005-01-26 | — | — | EP | claimed |
| US-20030236294-A1 | Compounds and methods for inducing apoptosis in proliferating cells | NIH - DEITR | 2003-12-25 | — | — | US | claimed |
| WO-2003086287-A2 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2003-10-23 | — | — | WO | claimed |
| US-20060142368-A1 | Compounds and methods for inducing apoptosis in proliferating cells | MRDC | 2006-06-29 | — | — | US | disclosed |
| US-7026346-B2 | Compounds and methods for inducing apoptosis in proliferating cells | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2006-04-11 | — | — | US | disclosed |
| US-20030236294-A1 | Compounds and methods for inducing apoptosis in proliferating cells | NIH - DEITR | 2003-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236294-A1 | Compounds and methods for inducing apoptosis in proliferating cells | MCL1, BRDT, BAD | PTGS2 392/4885PTGS1 298/4885PDPK1 1127/4885 |
| US-20060142368-A1 | Compounds and methods for inducing apoptosis in proliferating cells | MCL1, BRDT, BAD | PTGS2 370/4885PTGS1 303/4885PDPK1 1250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.