Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5675193 | 1.00 | MPL (0.42) | MPLSTAT1CYP1A2CYP2C19CA1 | |
| SCHEMBL7188373 | 0.87 | MAPT (0.44) | CYP1A2CYP2C19ALDH1A1LMNARAB9A | |
| SCHEMBL5673425 | 0.87 | MPL (0.44) | MPLSTAT1CYP1A2CYP2C19CA1 | |
| SCHEMBL5673730 | 0.87 | MPL (0.44) | MPLSTAT1CYP1A2CYP2C19CA1 | |
| SCHEMBL7246023 | 0.84 | MPL (0.62) | MPLSTAT1CYP1A2CYP2C19CA1 | |
| SCHEMBL7515436 | 0.83 | MPL (0.44) | MPLSTAT1CYP1A2CYP2C19CA1 | |
| SCHEMBL5673412 | 0.81 | LMNA (0.42) | MPLSTAT1CYP1A2CYP2C19CA1 | |
| SCHEMBL5673418 | 0.81 | LMNA (0.42) | MPLSTAT1CYP1A2CYP2C19CA1 | |
| SCHEMBL5672426 | 0.81 | LMNA (0.42) | MPLSTAT1CYP1A2CYP2C19CA1 | |
| SCHEMBL5672419 | 0.81 | LMNA (0.42) | MPLSTAT1CYP1A2CYP2C19CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1213965-B1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2006-01-18 | — | — | EP | claimed |
| US-6642265-B1 | Treating thrombocytopenia, in a mammal, including a human, by administering a hydroxy-1-azobenzene derivative | SMITHKLINE BEECHAM CORPORATION | 2003-11-04 | — | — | US | claimed |
| EP-1213965-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | claimed |
| EP-1213965-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-06-19 | — | — | EP | claimed |
| WO-2001017349-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BECKMAN CORPORATION (US) | 2001-03-15 | — | — | WO | claimed |
| EP-1213965-B1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2006-01-18 | — | — | EP | disclosed |
| US-6642265-B1 | Treating thrombocytopenia, in a mammal, including a human, by administering a hydroxy-1-azobenzene derivative | SMITHKLINE BEECHAM CORPORATION | 2003-11-04 | — | — | US | disclosed |
| EP-1213965-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-1213965-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017349-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BECKMAN CORPORATION (US) | 2001-03-15 | — | — | WO | disclosed |