Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.40 |
| ▸ | METTL14 | Q9HCE5 | 2/20 | 0.40 |
| ▸ | MPL | P40238 | 2/20 | 0.40 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5673412 | 1.00 | LMNA (0.42) | LMNAMAPTCYP1A2CYP2C19NPSR1 | |
| SCHEMBL5672419 | 0.91 | LMNA (0.42) | LMNAMAPTCYP1A2CYP2C19NPSR1 | |
| SCHEMBL5672426 | 0.91 | LMNA (0.42) | LMNAMAPTCYP1A2CYP2C19NPSR1 | |
| SCHEMBL5675194 | 0.81 | MPL (0.42) | LMNAMAPTCYP1A2CYP2C19METTL3 | |
| SCHEMBL5675193 | 0.81 | MPL (0.42) | LMNAMAPTCYP1A2CYP2C19METTL3 | |
| SCHEMBL5673468 | 0.80 | ALDH1A1 (0.43) | LMNAMAPTNPSR1ALDH1A1HTT | |
| SCHEMBL5673471 | 0.80 | ALDH1A1 (0.43) | LMNAMAPTNPSR1ALDH1A1HTT | |
| SCHEMBL5673425 | 0.80 | MPL (0.44) | LMNAMAPTCYP1A2CYP2C19NPSR1 | |
| SCHEMBL5673730 | 0.80 | MPL (0.44) | LMNAMAPTCYP1A2CYP2C19NPSR1 | |
| SCHEMBL5673351 | 0.79 | LMNA (0.39) | LMNAMAPTCYP1A2CYP2C19NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1213965-B1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2006-01-18 | — | — | EP | claimed |
| US-6642265-B1 | Treating thrombocytopenia, in a mammal, including a human, by administering a hydroxy-1-azobenzene derivative | SMITHKLINE BEECHAM CORPORATION | 2003-11-04 | — | — | US | claimed |
| EP-1213965-B1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2006-01-18 | — | — | EP | disclosed |
| US-6642265-B1 | Treating thrombocytopenia, in a mammal, including a human, by administering a hydroxy-1-azobenzene derivative | SMITHKLINE BEECHAM CORPORATION | 2003-11-04 | — | — | US | disclosed |
| EP-1213965-A4 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-1213965-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001017349-A1 | THROMBOPOIETIN MIMETICS | SMITHKLINE BECKMAN CORPORATION (US) | 2001-03-15 | — | — | WO | disclosed |