Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 14/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5675450 | 1.00 | HDAC8 (0.41) | HDAC8PPARGHDAC6 | |
| SCHEMBL6134996 | 1.00 | HDAC8 (0.41) | HDAC8PPARGHDAC6 | |
| SCHEMBL5673036 | 0.93 | PPARG (0.41) | HDAC8PPARG | |
| SCHEMBL5673033 | 0.93 | PPARG (0.41) | HDAC8PPARG | |
| SCHEMBL5672937 | 0.90 | PPARG (0.40) | HDAC8PPARG | |
| SCHEMBL5672940 | 0.90 | PPARG (0.40) | HDAC8PPARG | |
| SCHEMBL5675442 | 0.89 | PPARG (0.37) | HDAC8PPARG | |
| SCHEMBL5675438 | 0.89 | PPARG (0.37) | HDAC8PPARG | |
| SCHEMBL5673941 | 0.88 | HDAC8 (0.39) | HDAC8PPARGHDAC6 | |
| SCHEMBL5673937 | 0.88 | HDAC8 (0.39) | HDAC8PPARGHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005082414-A2 | CONCOMITANT DRUGS OF A SULFONAMIDE AND ANOTHER THERAPEUTIC AGENT | ASTELLAS PHARMA INC. (JP) | 2005-09-09 | — | — | WO | claimed |
| US-20050197376-A1 | Concomitant drugs | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2005-09-08 | — | — | US | claimed |
| EP-1142879-A1 | IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | claimed |
| US-7060721-B1 | Imidazole compounds and medicinal use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2006-06-13 | — | — | US | disclosed |
| US-20050197376-A1 | Concomitant drugs | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2005-09-08 | — | — | US | disclosed |
| EP-1142879-A1 | IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |