Sugi Predict

Sugi Predict / Compounds / SCHEMBL5675465

SCHEMBL5675465

SCHEMBL5675465

CCCOc1ccc(Cn2c(C)nc(Cl)c2/C=C/C(=O)NS(=O)(=O)c2ccc(C)cc2)c(Cl)c1

nearest known ligand 0.39

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ HRH3 Q9Y5N1 2/20 0.38
▸ PTGER3 P43115 9/20 0.38
▸ BCL2L1 Q07817 1/20 0.38
▸ MCL1 Q07820 1/20 0.38
▸ PPARG P37231 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5675467 1.00 HRH3 (0.38) HRH3PTGER3BCL2L1MCL1PPARG
SCHEMBL5672601 0.95 PPARG (0.41) HRH3PTGER3BCL2L1MCL1PPARG
SCHEMBL5672598 0.95 PPARG (0.41) HRH3PTGER3BCL2L1MCL1PPARG
SCHEMBL5673719 0.88 S1PR1 (0.43) PTGER3BCL2L1MCL1
SCHEMBL5673725 0.88 S1PR1 (0.43) PTGER3BCL2L1MCL1
SCHEMBL5672537 0.87 BCL2L1 (0.43) HRH3PTGER3BCL2L1MCL1
SCHEMBL5672531 0.87 BCL2L1 (0.43) HRH3PTGER3BCL2L1MCL1
SCHEMBL5672933 0.86 BCL2L1 (0.44) HRH3PTGER3BCL2L1MCL1
SCHEMBL5672936 0.86 BCL2L1 (0.44) HRH3PTGER3BCL2L1MCL1
SCHEMBL5672638 0.85 PTGES (0.41) PTGER3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7060721-B1 Imidazole compounds and medicinal use thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2006-06-13 — — US disclosed
EP-1142879-A1 IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-10-10 — — EP disclosed