Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 3/20 | 0.64 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.62 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL313164 | 0.95 | PLOD2 (0.70) | PLOD2PLOD3PLOD1PTPN1GSK3B | |
| SCHEMBL31492946 | 0.89 | RXRA (0.61) | PLOD2PLOD3PLOD1PTPN1GSK3B | |
| SCHEMBL6666160 | 0.84 | PLOD2 (0.66) | PLOD2PLOD3PLOD1PTPN1GSK3B | |
| SCHEMBL29987081 | 0.83 | PTPN1 (0.75) | PLOD2PTPN1GSK3BMMP1CES2 | |
| SCHEMBL11139436 | 0.83 | PTPN1 (0.60) | PTPN1GSK3BMMP1CES2CES1 | |
| SCHEMBL11137727 | 0.83 | PLOD2 (0.64) | PLOD2PLOD3PLOD1GSK3BCES2 | |
| SCHEMBL19919893 | 0.81 | PTPN1 (0.67) | PLOD2PLOD3PLOD1PTPN1GSK3B | |
| SCHEMBL31019373 | 0.81 | PTPN1 (0.62) | PLOD2PLOD3PLOD1PTPN1GSK3B | |
| SCHEMBL28718057 | 0.81 | PLOD2 (0.66) | PLOD2PLOD3PLOD1PTPN1HDAC1 | |
| SCHEMBL11137241 | 0.80 | PTPN1 (0.57) | PTPN1GSK3BMMP1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060142368-A1 | Compounds and methods for inducing apoptosis in proliferating cells | MRDC | 2006-06-29 | — | — | US | disclosed |
| US-7026346-B2 | Compounds and methods for inducing apoptosis in proliferating cells | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2006-04-11 | — | — | US | disclosed |
| EP-1499597-A4 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | UNIV OHIO STATE RES FOUND (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1499597-A2 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2005-01-26 | — | — | EP | disclosed |
| US-20030236294-A1 | Compounds and methods for inducing apoptosis in proliferating cells | NIH - DEITR | 2003-12-25 | — | — | US | disclosed |
| WO-2003086287-A2 | COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2003-10-23 | — | — | WO | disclosed |
| US-4382012-A | Liquid crystalline diketones | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1983-05-03 | — | — | US | disclosed |
| US-4297515-A | Diketones useful as liquid crystals | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236294-A1 | Compounds and methods for inducing apoptosis in proliferating cells | MCL1, BRDT, BAD | PLOD2 3718/4885PLOD3 4097/4885PLOD1 3548/4885 |
| US-20060142368-A1 | Compounds and methods for inducing apoptosis in proliferating cells | MCL1, BRDT, BAD | PLOD2 3666/4885PLOD3 3975/4885PLOD1 3429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.