Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869844 | 0.97 | — | — | |
| SCHEMBL2550145 | 0.94 | — | — | |
| SCHEMBL15355221 | 0.91 | CXCR4 (0.47) | CXCR4SMN1; SMN2ALDH1A1HIF1AMAPT | |
| Pyrrolidine SCHEMBL14809175 | 0.91 | ALDH1A1 (0.53) | CXCR4SMN1; SMN2ALDH1A1HIF1AMAPT | |
| SCHEMBL29016828 | 0.91 | ALDH1A1 (0.53) | CXCR4SMN1; SMN2ALDH1A1HIF1AMAPT | |
| Thiomorpholine SCHEMBL6624599 | 0.91 | ALDH1A1 (0.53) | CXCR4SMN1; SMN2ALDH1A1HIF1AMAPT | |
| SCHEMBL12100700 | 0.88 | — | — | |
| SCHEMBL138572 | 0.88 | — | — | |
| SCHEMBL11392517 | 0.88 | ALDH1A1 (0.41) | CXCR4SMN1; SMN2ALDH1A1HIF1AMAPT | |
| SCHEMBL12882833 | 0.88 | CXCR4 (0.41) | CXCR4SMN1; SMN2ALDH1A1HIF1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615920-A1 | 3-BENZHYDRYLIDENE-8-AZA-BICYCLO [3.2.1] OCTANE DERIVATIVES WITH OPIOID RECEPTOR ACTIVITY | Pfizer Products Inc. (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004092165-A1 | 3-BENZHYDRYLIDENE-8-AZA-BICYCLO[3.2.1]OCTANE DERIVATIVES WITH OPIOID RECEPTOR ACTIVITY | PFIZER PRODUCTS INC. (US) | 2004-10-28 | — | — | WO | disclosed |
| EP-1112255-A1 | 4,4-BIARYLPIPERIDINE DERIVATIVES WITH OPIOID RECEPTOR ACTIVITY | Pfizer Products Inc. (US) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000014066-A1 | 4,4-BIARYLPIPERIDINE DERIVATIVES WITH OPIOID RECEPTOR ACTIVITY | PFIZER PRODUCTS INC. (US) | 2000-03-16 | — | — | WO | disclosed |