Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.46 |
| ▸ | BRD4 | O60885 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679666 | 1.00 | DYRK1A (0.46) | DYRK1ABRD4KDM4EALDH1A1HPGD | |
| SCHEMBL5678047 | 0.83 | GLS (0.43) | BRD4KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL5677709 | 0.83 | AAK1 (0.36) | SLC22A12 | |
| SCHEMBL5677704 | 0.83 | AAK1 (0.36) | SLC22A12 | |
| SCHEMBL5679771 | 0.79 | SLC22A12 (0.38) | KDM4EALDH1A1HPGDSLC22A12HSD17B10 | |
| SCHEMBL5679765 | 0.79 | SLC22A12 (0.38) | KDM4EALDH1A1HPGDSLC22A12HSD17B10 | |
| SCHEMBL6360911 | 0.78 | HTR2A (0.42) | DYRK1ASLC22A12 | |
| SCHEMBL5679757 | 0.76 | AAK1 (0.41) | ALDH1A1SLC22A12 | |
| SCHEMBL5679751 | 0.76 | AAK1 (0.41) | ALDH1A1SLC22A12 | |
| SCHEMBL7094181 | 0.76 | HTR2A (0.40) | DYRK1ASLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129078-B1 | INDAZOLE DERIVATIVES WITH 5-HT2 RECEPTOR ACTIVITY | VERNALIS RES LTD (GB) | 2006-03-15 | — | — | EP | disclosed |
| US-6552062-B1 | For therapy of central nervous system disorders; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and obesity | VERNALIS RESEARCH LIMITED (GB) | 2003-04-22 | — | — | US | disclosed |