Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 9/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679765 | 1.00 | SLC22A12 (0.38) | SLC22A12MAPTHPGDALDH1A1KDM4E | |
| SCHEMBL5677709 | 0.92 | AAK1 (0.36) | SLC22A12KMOAAK1LMNAPTGDR2 | |
| SCHEMBL5677704 | 0.92 | AAK1 (0.36) | SLC22A12KMOAAK1LMNAPTGDR2 | |
| SCHEMBL5678047 | 0.79 | GLS (0.43) | MAPTHPGDALDH1A1KDM4EGAA | |
| SCHEMBL5679666 | 0.79 | DYRK1A (0.46) | SLC22A12HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5679657 | 0.79 | DYRK1A (0.46) | SLC22A12HPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8904901 | 0.75 | HTR2C (0.56) | MAPTHPGDALDH1A1KDM4EGAA | |
| SCHEMBL905951 | 0.74 | HTR2A (0.49) | SLC22A12 | |
| SCHEMBL5678084 | 0.73 | BRD4 (0.37) | SLC22A12MAPTALDH1A1AAK1LMNA | |
| SCHEMBL5678090 | 0.73 | BRD4 (0.37) | SLC22A12MAPTALDH1A1AAK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129078-B1 | INDAZOLE DERIVATIVES WITH 5-HT2 RECEPTOR ACTIVITY | VERNALIS RES LTD (GB) | 2006-03-15 | — | — | EP | disclosed |
| US-6552062-B1 | For therapy of central nervous system disorders; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and obesity | VERNALIS RESEARCH LIMITED (GB) | 2003-04-22 | — | — | US | disclosed |