SCHEMBL5683291

SCHEMBL5683291

COC(=O)CC(C)(C)C=CC(Cl)(Cl)C(F)(F)F

nearest known ligand 0.31

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5683289 1.00 TSHR (0.31) TSHR
SCHEMBL5683340 0.83 GAA (0.35)
SCHEMBL5686092 0.83
SCHEMBL27494444 0.83
SCHEMBL5686096 0.83
SCHEMBL5683344 0.83 GAA (0.35)
SCHEMBL11067787 0.82 TSHR (0.36) TSHR
SCHEMBL11067789 0.82 TSHR (0.36) TSHR
SCHEMBL8571513 0.80 HMGCR (0.37) TSHR
SCHEMBL8571510 0.80 HMGCR (0.37) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0832873-B1 Preparation of cyclopropane esters SYNGENTA LTD (GB) 2006-03-08 EP disclosed
EP-0793638-B1 PREPARATION OF CYCLOPROPANE ESTERS ZENECA LTD (GB) 1999-06-30 EP disclosed
CN-1220255-A Preparation of cyclopropane esters ZENECA LTD (GB) 1999-06-23 CN disclosed
EP-0700375-B1 PREPARATION OF CYCLOPROPANE ESTERS ZENECA LTD (GB) 1998-12-23 EP disclosed
EP-0793637-B1 HALOGENATED ESTERS USEFUL AS INTERMEDIATES FOR INSECTICIDES ZENECA LTD (GB) 1998-10-28 EP disclosed
US-5756835-A Halogenated esters useful as intermediates for insecticides ZENECA LIMITED (GB) 1998-05-26 US disclosed
US-5750769-A Halogenated esters useful as intermediates for insecticides ZENECA LIMITED (GB) 1998-05-12 US disclosed
EP-0700373-B1 PREPARATION OF HALOGENATED ALCOHOLS ZENECA LTD (GB) 1998-04-22 EP disclosed
EP-0832873-A1 Preparation of cyclopropane esters ZENECA LIMITED (GB) 1998-04-01 EP disclosed
US-5731475-A Preparation of cyclopropane esters ZENECA LIMITED (GB) 1998-03-24 US disclosed
US-5670697-A Preparation of cyclopropane esters ZENECA LIMITED (GB) 1997-09-23 US disclosed
EP-0793637-A1 HALOGENATED ESTERS USEFUL AS INTERMEDIATES FOR INSECTICIDES ZENECA LIMITED (GB) 1997-09-10 EP disclosed
EP-0793638-A1 PREPARATION OF CYCLOPROPANE ESTERS ZENECA LIMITED (GB) 1997-09-10 EP disclosed
US-5527972-A Preparation and use of halogenated alcohols ZENECA LIMITED (GB) 1996-06-18 US disclosed
WO-1996016925-A1 HALOGENATED ESTERS USEFUL AS INTERMEDIATES FOR INSECTICIDES ZENECA LIMITED (GB) 1996-06-06 WO disclosed
WO-1996016018-A1 PREPARATION OF CYCLOPROPANE ESTERS ZENECA LIMITED (GB) 1996-05-30 WO disclosed
EP-0700375-A1 PREPARATION OF CYCLOPROPANE ESTERS ZENECA LIMITED (GB) 1996-03-13 EP disclosed
EP-0700373-A1 PREPARATION OF HALOGENATED ALCOHOLS ZENECA LIMITED (GB) 1996-03-13 EP disclosed
WO-1994027951-A1 PREPARATION OF CYCLOPROPANE ESTERS ZENECA LIMITED (GB) 1994-12-08 WO disclosed
WO-1994027942-A1 PREPARATION OF HALOGENATED ALCOHOLS ZENECA LIMITED (GB) 1994-12-08 WO disclosed