Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 7/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653620 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2HRH2TSHRDRD2HRH1 | |
| SCHEMBL4595629 | 0.82 | GAA (0.51) | SMN1; SMN2TSHRPOLBMAPTCYP1A2 | |
| SCHEMBL5835647 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2HRH2TSHRDRD2HRH1 | |
| SCHEMBL2873838 | 0.77 | HTT (0.46) | SMN1; SMN2TSHRALDH1A1MAPTHTT | |
| SCHEMBL13851673 | 0.76 | HRH2 (0.52) | SMN1; SMN2HRH2TSHRDRD2HRH1 | |
| SCHEMBL3255716 | 0.74 | SMN1; SMN2 (0.60) | SMN1; SMN2HRH2TSHRPOLBALDH1A1 | |
| SCHEMBL307251 | 0.74 | — | — | |
| SCHEMBL4594749 | 0.73 | SMN1; SMN2 (0.55) | SMN1; SMN2HRH2TSHRDRD2HRH1 | |
| SCHEMBL5653356 | 0.73 | CCNE1 (0.39) | SMN1; SMN2TSHRALDH1A1 | |
| Bromide SCHEMBL5048845 | 0.73 | SMN1; SMN2 (0.58) | SMN1; SMN2HRH2TSHRPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1640369-A1 | THIAZOLIMINE COMPOUND AND OXAZOLIMINE COMPOUND | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2006-03-29 | — | — | EP | disclosed |