Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047440 | 0.86 | MAP3K7 (0.39) | MAPK14PTK2ALDH1A1NPSR1HSD17B10 | |
| SCHEMBL5685202 | 0.85 | BRAF (0.47) | MAPK14BRAFPTK2GSK3AALDH1A1 | |
| SCHEMBL5682611 | 0.85 | MAPK14 (0.52) | MAPK14BRAFGSK3A | |
| SCHEMBL5119462 | 0.82 | MAPK14 (0.39) | MAPK14PTK2ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL5125191 | 0.79 | ACHE (0.43) | MAPK14ALDH1A1NPSR1HSD17B10 | |
| SCHEMBL5114170 | 0.78 | ACHE (0.36) | MAPK14ALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL13688795 | 0.77 | BRAF (0.37) | MAPK14BRAFPTK2GSK3A | |
| SCHEMBL14276192 | 0.77 | MAPK14 (0.45) | MAPK14PTK2GSK3A | |
| SCHEMBL13688769 | 0.77 | MAPK14 (0.40) | MAPK14BRAFPTK2 | |
| SCHEMBL13688785 | 0.76 | MAPK14 (0.39) | MAPK14BRAFPTK2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631567-A2 | HETEROCYCLIC N-ARYL CARBOXAMIDES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-03-08 | — | — | EP | claimed |
| WO-2005016918-A2 | HETEROCYCLIC N-ARYL CARBOXAMIDES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-02-24 | — | — | WO | claimed |