Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | STAT6 | P42226 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494959 | 0.87 | STAT6 (0.59) | SYKJAK3STAT6TTKPTK2 | |
| SCHEMBL5686069 | 0.81 | SYK (0.53) | SYKJAK3KCNH2 | |
| SCHEMBL16464804 | 0.81 | SYK (0.78) | SYK | |
| SCHEMBL16304063 | 0.80 | KCNH2 (0.54) | PARP1HRH3KCNH2 | |
| SCHEMBL28833626 | 0.80 | JAK3 (0.57) | LCKJAK3EGFRBTKPARP1 | |
| SCHEMBL17899154 | 0.76 | PARP1 (0.42) | SYKLCKJAK3EGFRBTK | |
| SCHEMBL28324041 | 0.74 | MAP4K1 (0.42) | LCKJAK3EGFRBTKPTK2 | |
| SCHEMBL19824672 | 0.74 | JAK3 (0.74) | LCKJAK3EGFRBTK | |
| SCHEMBL30962842 | 0.71 | WEE1 (0.51) | SYKLCKJAK3STAT6TTK | |
| SCHEMBL16466285 | 0.70 | SYK (0.74) | SYKJAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903970-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014058921-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2014-04-17 | — | — | WO | disclosed |
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |