Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT6 | P42226 | 1/20 | 0.59 |
| ▸ | TTK | P33981 | 1/20 | 0.59 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.57 |
| ▸ | SYK | P43405 | 2/20 | 0.53 |
| ▸ | FLT4 | P35916 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.49 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.49 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5686231 | 0.87 | SYK (0.50) | STAT6TTKMAP4K1PTK2SYK | |
| SCHEMBL30962842 | 0.83 | WEE1 (0.51) | STAT6TTKMAP4K1PTK2SYK | |
| SCHEMBL30560067 | 0.80 | MAP4K1 (0.50) | STAT6TTKMAP4K1MAP4K3TBK1 | |
| SCHEMBL4492001 | 0.80 | SYK (0.62) | STAT6TTKPTK2SYKKDR | |
| SCHEMBL17076546 | 0.80 | SYK (0.82) | STAT6SYK | |
| SCHEMBL2427453 | 0.78 | HDAC3 (0.57) | KDM1AMAOAKDM1BRCOR1EML4 | |
| SCHEMBL17005759 | 0.77 | SYK (0.55) | MAP4K1PTK2SYK | |
| SCHEMBL19133765 | 0.76 | PARP1 (0.44) | JAK3 | |
| SCHEMBL5686325 | 0.76 | RAB9A (0.56) | SYKJAK3 | |
| SCHEMBL4489867 | 0.75 | BRD4 (0.61) | STAT6PTK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504396-B2 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2009-03-17 | — | — | US | disclosed |
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| US-20050209221-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2005-09-22 | — | — | US | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209221-A1 | Substituted heterocyclic compounds and methods of use | ICOS, CD4, HLA-DRB1 | STAT6 564/4885TTK 3470/4885MAP4K1 1442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.