Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CBX7 | O95931 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4496196 | 0.73 | NPC1 (0.45) | ALDH1A1POLBL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL5824566 | 0.71 | KDR (0.57) | — | |
| SCHEMBL1930008 | 0.68 | ALDH1A1 (0.69) | ALDH1A1POLBL3MBTL1TDP1SMN1; SMN2 | |
| SCHEMBL13946459 | 0.68 | SMN1; SMN2 (0.64) | ALDH1A1POLBL3MBTL1TDP1SMN1; SMN2 | |
| SCHEMBL5056246 | 0.67 | ALDH1A1 (0.69) | ALDH1A1TDP1TP53SMN1; SMN2KDM4E | |
| SCHEMBL31582882 | 0.67 | NNMT (0.45) | ALDH1A1POLBTDP1KDM4EHPGD | |
| SCHEMBL30509874 | 0.67 | NNMT (0.45) | ALDH1A1POLBTDP1KDM4EHPGD | |
| SCHEMBL5056153 | 0.66 | CYP3A4 (0.62) | ALDH1A1TP53SMN1; SMN2KDM4EMAPT | |
| SCHEMBL4501636 | 0.66 | MKNK1 (0.46) | L3MBTL1HPGDMAPTLMNAMEN1 | |
| SCHEMBL5753229 | 0.66 | ALDH1A1 (0.69) | ALDH1A1POLBL3MBTL1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |