Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.56 |
| ▸ | NQO2 | P16083 | 3/20 | 0.54 |
| ▸ | NQO1 | P15559 | 1/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 7/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.51 |
| ▸ | ABL1 | P00519 | 7/20 | 0.51 |
| ▸ | BCR | P11274 | 7/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.51 |
| ▸ | TTR | P02766 | 3/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5686554 | 1.00 | ALOX5 (0.56) | ALOX5NQO2NQO1CYP1A1CYP1B1 | |
| SCHEMBL5686546 | 1.00 | ALOX5 (0.56) | ALOX5NQO2NQO1CYP1A1CYP1B1 | |
| SCHEMBL5686615 | 0.83 | TUBB1 (0.72) | NQO2CYP1A1CYP1B1ABCB1KDM4E | |
| SCHEMBL5686608 | 0.83 | TUBB1 (0.72) | NQO2CYP1A1CYP1B1ABCB1KDM4E | |
| SCHEMBL5686624 | 0.83 | TUBB1 (0.72) | NQO2CYP1A1CYP1B1ABCB1KDM4E | |
| SCHEMBL38654906 | 0.83 | TUBB1 (0.72) | NQO2CYP1A1CYP1B1ABCB1KDM4E | |
| SCHEMBL5687379 | 0.82 | TUBB1 (0.70) | NQO2CYP1A1CYP1B1ABCB1KDM4E | |
| SCHEMBL5686435 | 0.76 | TUBB1 (0.62) | ALOX5NQO2NQO1CYP1A1ABCB1 | |
| SCHEMBL5686440 | 0.76 | TUBB1 (0.62) | ALOX5NQO2NQO1CYP1A1ABCB1 | |
| SCHEMBL5686444 | 0.76 | TUBB1 (0.62) | ALOX5NQO2NQO1CYP1A1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060160773-A1 | Combretastatin derivatives with cytotoxic action | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-07-20 | — | — | US | claimed |
| EP-1646616-A2 | COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2006-04-19 | — | — | EP | claimed |
| WO-2005007635-A2 | COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2005-01-27 | — | — | WO | claimed |
| EP-1646616-A2 | COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005007635-A2 | COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2005-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160773-A1 | Combretastatin derivatives with cytotoxic action | TUBB, TUBB1, TYMS | ALOX5 3403/4885NQO2 1226/4885NQO1 1604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.