Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 7/20 | 0.69 |
| ▸ | ESR1 | P03372 | 10/20 | 0.68 |
| ▸ | STS | P08842 | 3/20 | 0.68 |
| ▸ | ENPP1 | P22413 | 6/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | PLD2 | O14939 | 1/20 | 0.61 |
| ▸ | KDM1A | O60341 | 1/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | C5 | P01031 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | PGR | P06401 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18872885 | 0.91 | ESR1 (0.81) | ENPP3ESR1STSENPP1ESR2 | |
| SCHEMBL5689501 | 0.90 | ESR1 (0.63) | ENPP3ESR1STSENPP1ESR2 | |
| SCHEMBL6836622 | 0.89 | ENPP3 (0.78) | ENPP3ESR1STSENPP1ESR2 | |
| SCHEMBL2404570 | 0.88 | ESR1 (0.79) | ESR1ESR2MEN1PLD2KDM1A | |
| SCHEMBL2407930 | 0.88 | ESR1 (0.77) | ESR1STSESR2MEN1PLD2 | |
| SCHEMBL29627141 | 0.88 | ESR1 (0.77) | ESR1STSESR2MEN1PLD2 | |
| SCHEMBL12269725 | 0.87 | ESR1 (0.67) | ENPP3ESR1ESR2MEN1PLD2 | |
| SCHEMBL12269742 | 0.83 | ESR1 (0.62) | ENPP3ESR1ESR2MEN1PLD2 | |
| SCHEMBL8613942 | 0.83 | ENPP3 (0.47) | ENPP3ESR1STSENPP1ESR2 | |
| SCHEMBL1439001 | 0.83 | ENPP3 (0.87) | ENPP3ESR1STSENPP1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835871-B1 | Benzo [b] thiophene compounds, intermediates, formulations, and methods | LILLY CO ELI (US) | 2006-03-01 | — | — | EP | claimed |
| US-6017914-A | Benzo[b]thiophene compounds, intermediates, formulations, and methods | ELI LILLY AND COMPANY (US) | 2000-01-25 | — | — | US | claimed |
| EP-0835871-A1 | Benzo [b] thiophene compounds, intermediates, formulations, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | claimed |
| EP-0835871-B1 | Benzo [b] thiophene compounds, intermediates, formulations, and methods | LILLY CO ELI (US) | 2006-03-01 | — | — | EP | disclosed |
| EP-0835878-B1 | Benzo (b) thiophene compounds, intermediates, formulations, and methods | LILLY CO ELI (US) | 2002-12-11 | — | — | EP | disclosed |
| US-6265575-B1 | THROMBIN INHIBITORS | ELI LILLY AND COMPANY | 2001-07-24 | — | — | US | disclosed |
| US-6251921-B1 | ADMINISTERING THROMBIN INHIBITING DIAMINE COMPOUND TO MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-6025382-A | Antithrombotic diamines | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |
| US-6017914-A | Benzo[b]thiophene compounds, intermediates, formulations, and methods | ELI LILLY AND COMPANY (US) | 2000-01-25 | — | — | US | disclosed |
| EP-0835878-A1 | Benzo (b) thiophene compounds, intermediates, formulations, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |
| EP-0835871-A1 | Benzo [b] thiophene compounds, intermediates, formulations, and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |