Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 7/20 | 0.78 |
| ▸ | ESR1 | P03372 | 9/20 | 0.75 |
| ▸ | STS | P08842 | 3/20 | 0.75 |
| ▸ | ENPP1 | P22413 | 6/20 | 0.74 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.69 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | PLD2 | O14939 | 1/20 | 0.65 |
| ▸ | KDM1A | O60341 | 1/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | C5 | P01031 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | FYN | P06241 | 1/20 | 0.65 |
| ▸ | PGR | P06401 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18872885 | 0.96 | ESR1 (0.81) | ENPP3ESR1STSENPP1ESR2 | |
| SCHEMBL1439001 | 0.94 | ENPP3 (0.87) | ENPP3ESR1STSENPP1ESR2 | |
| SCHEMBL10827879 | 0.94 | ENPP3 (0.87) | ENPP3ESR1STSENPP1ESR2 | |
| Hydrochloric Acid SCHEMBL1438899 | 0.94 | ENPP3 (0.85) | ENPP3ESR1STSENPP1ESR2 | |
| SCHEMBL10827744 | 0.93 | ENPP3 (0.85) | ENPP3ESR1STSENPP1ESR2 | |
| SCHEMBL8596738 | 0.91 | ENPP3 (0.79) | ENPP3ESR1STSENPP1ESR2 | |
| SCHEMBL5686648 | 0.89 | ENPP3 (0.69) | ENPP3ESR1STSENPP1ESR2 | |
| SCHEMBL4608181 | 0.89 | STS (0.84) | ENPP3ESR1STSESR2ABCC1 | |
| SCHEMBL10828093 | 0.86 | ENPP3 (0.73) | ENPP3ESR1STSENPP1ESR2 | |
| SCHEMBL10827833 | 0.85 | ENPP3 (0.85) | ENPP3ESR1STSENPP1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756388-B1 | HAVING PIPERIDINYL AND PHENOLIC FUNCTIONALITY; BONE LOSS; BREAST OR PROSTATE CANCER | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |
| EP-0723537-A1 | BENZOTHIOPHENES AND RELATED COMPOUNDS AS ESTROGEN AGONISTS | PFIZER INC. (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010513-A1 | BENZOTHIOPHENES AND RELATED COMPOUNDS AS ESTROGEN AGONISTS | PFIZER INC. (US) | 1995-04-20 | — | — | WO | disclosed |