SCHEMBL5688802

SCHEMBL5688802

CCNC(=O)c1cccc(-c2ccc(C(O)(c3cn(C(c4ccccc4)(c4ccccc4)c4ccccc4)cn3)C(C)C)cc2)c1

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP17A1 P05093 5/20 0.45
CYP3A4 P08684 4/20 0.45
CDK8 P49336 1/20 0.40
ACSS2 Q9NR19 1/20 0.39
DAGLA Q9Y4D2 1/20 0.39
IP6K1 Q92551 1/20 0.38
SIRT2 Q8IXJ6 6/20 0.37
TTK P33981 1/20 0.37
LOXL2 Q9Y4K0 1/20 0.37
SENP1 Q9P0U3 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5688583 0.90 CYP17A1 (0.56) CYP17A1CYP3A4CDK8SIRT2
SCHEMBL5691363 0.89 CYP3A4 (0.46) CYP17A1CYP3A4ACSS2SIRT2
SCHEMBL5688616 0.88 CYP17A1 (0.43) CYP17A1CYP3A4CDK8SIRT2
SCHEMBL5688655 0.86 CYP17A1 (0.44) CYP17A1CYP3A4ACSS2TTK
SCHEMBL4024055 0.86 CYP17A1 (0.55) CYP17A1CYP3A4ACSS2SIRT2
SCHEMBL5688570 0.84 CYP17A1 (0.48) CYP17A1CYP3A4CDK8ACSS2SIRT2
SCHEMBL5690711 0.83 P2RY12 (0.41) CYP17A1SIRT2
SCHEMBL5688983 0.83 CYP3A4 (0.44) CYP17A1CYP3A4SIRT2
SCHEMBL5691341 0.82 SIRT2 (0.44) CYP17A1CYP3A4ACSS2SIRT2
SCHEMBL5689005 0.82 CYP17A1 (0.55) CYP17A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1227086-B1 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF TAKEDA PHARMACEUTICAL (JP) 2006-03-29 EP disclosed
US-6518257-B1 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2003-02-11 US disclosed
EP-1227086-A1 1-SUBSTITUTED PHENYL-1-(1H-IMIDAZOL-4-YL) ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2002-07-31 EP disclosed