Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29456085 | 0.83 | RNPEP (0.54) | FOLH1LMNARNPEPALDH1A1GAA | |
| SCHEMBL7057087 | 0.82 | LMNA (0.49) | FOLH1LMNARNPEPALDH1A1GAA | |
| SCHEMBL27602423 | 0.81 | FOLH1 (0.58) | FOLH1LMNARNPEPALDH1A1GAA | |
| SCHEMBL28558204 | 0.80 | RNPEP (0.50) | FOLH1LMNARNPEPALDH1A1GAA | |
| SCHEMBL5988220 | 0.79 | KDM4E (0.39) | LMNARNPEPALDH1A1GAANPSR1 | |
| SCHEMBL31285813 | 0.78 | FOLH1 (0.44) | FOLH1LMNARNPEPALDH1A1GAA | |
| SCHEMBL29572781 | 0.76 | LMNA (0.43) | FOLH1LMNARNPEPALDH1A1GAA | |
| SCHEMBL8928051 | 0.75 | RNPEP (0.54) | FOLH1LMNARNPEPALDH1A1GAA | |
| SCHEMBL30754260 | 0.75 | FOLH1 (0.51) | FOLH1LMNARNPEPALDH1A1NPSR1 | |
| SCHEMBL9194550 | 0.75 | RNPEP (0.55) | FOLH1LMNARNPEPALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633743-A1 | CYCLIC AMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATION-RELATED DISORDERS MEDIATED BY BRADYKININ | Amgen, Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004092164-A1 | CYCLIC AMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF INFLAMMATION-RELATED DISORDERS MEDIATED BY BRADYKININ | AMGEN, INC. (US) | 2004-10-28 | — | — | WO | disclosed |