SCHEMBL5689000

SCHEMBL5689000

COC(=O)Nc1ccc(Br)cn1

nearest known ligand 0.60

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 11/20 0.60
NPC1 O15118 9/20 0.60
MAPT P10636 2/20 0.56
TSHR P16473 2/20 0.55
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
RXFP1 Q9HBX9 1/20 0.55
TP53 P04637 1/20 0.55
MAPK1 P28482 1/20 0.55
KDM4E B2RXH2 1/20 0.55
LMNA P02545 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
CASP3 P42574 1/20 0.51
SENP7 Q9BQF6 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11840192 0.83 RAB9A (0.52) RAB9ANPC1MAPTTSHRMEN1
SCHEMBL283737 0.83 RAB9A (0.51) RAB9ANPC1MAPTTSHRMEN1
SCHEMBL29372377 0.83 RAB9A (0.51) RAB9ANPC1MAPTTSHRMEN1
SCHEMBL8986532 0.83 RAB9A (0.59) RAB9ANPC1MAPTTSHRMEN1
SCHEMBL1197755 0.83 TSHR (0.53) RAB9ANPC1MAPTTSHRMEN1
SCHEMBL1503823 0.83 RAB9A (0.57) RAB9ANPC1MAPTTSHRMEN1
SCHEMBL29883001 0.81 PTK2 (0.62) RAB9ANPC1TSHRMEN1KMT2A
SCHEMBL356367 0.81 PTK2 (0.62) RAB9ANPC1TSHRMEN1KMT2A
SCHEMBL11845438 0.81 RAB9A (0.59) RAB9ANPC1MAPTTSHRMEN1
SCHEMBL6613670 0.80 RAB9A (0.62) RAB9ANPC1MAPTTSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250340551-A1 SMALL MOLECULE MODULATORS OF STAT6 GILEAD SCIENCES INC (US) 2025-11-06 US disclosed
US-20250325677-A1 STAT6 DEGRADERS GILEAD SCIENCES INC (US) 2025-10-23 US disclosed
CN-112608299-A Synthesis method of 4- (6-aminopyridine-3-yl) piperidine-1-tert-butyl formate 山东铂源药业有限公司 2021-04-06 CN disclosed
CN-112608299-A Synthesis method of 4- (6-aminopyridine-3-yl) piperidine-1-tert-butyl formate 山东铂源药业有限公司 2021-04-06 CN disclosed
WO-2016161282-A1 HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS INCYTE CORPORATION (US) 2016-10-06 WO disclosed
EP-0938476-B1 PROCESS FOR SUBSTITUTED PYRIDINES PFIZER (US) 2006-03-08 EP disclosed
US-6291489-B1 USEFUL IN THE SYNTHESIS OF CERTAIN .BETA.-ADRENERGIC RECEPTOR AGONISTS PFIZER INC. 2001-09-18 US disclosed
US-6001856-A β-adrenergic agonists to reduce a wasting condition PFIZER INC. (US) 1999-12-14 US disclosed
EP-0938476-A1 PROCESS FOR SUBSTITUTED PYRIDINES PFIZER INC. (US) 1999-09-01 EP disclosed
EP-0887079-A1 Beta-Adrenergic agonists to reduce a wasting condition PFIZER INC. (US) 1998-12-30 EP disclosed
WO-1998021184-A1 PROCESS FOR SUBSTITUTED PYRIDINES PFIZER INC. (US) 1998-05-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250325677-A1 STAT6 DEGRADERS STAT6, STAT5B, STAT1 RAB9A 4378/4885NPC1 2139/4885MAPT 1017/4885
US-20250340551-A1 SMALL MOLECULE MODULATORS OF STAT6 STAT6, STAT1, STAT5B RAB9A 3014/4885NPC1 1677/4885MAPT 1682/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.