Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.44 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.44 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL3996469 | 0.96 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL3311729 | 0.96 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL3022684 | 0.96 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL223345 | 0.96 | CA4 (0.47) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL6383360 | 0.93 | CA4 (0.39) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL5187484 | 0.92 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL4728488 | 0.92 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL2161269 | 0.92 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL3121145 | 0.92 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL5943682 | 0.92 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136302-A | MIXING A ZIRCONIUM SALT AND AN ALUMINUM SALT TO FORM A ZIRCONIUM-ALUMINUM SALT | THE PROCTER & GAMBLE COMPANY (US) | 2000-10-24 | — | — | US | claimed |
| US-20150342989-A1 | COMPOSITIONS COMPRISING NON STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF | ALEX PHILIP (US) | 2015-12-03 | — | — | US | disclosed |
| US-9084769-B2 | Compositions comprising non steroidal anti-inflammatory drugs and methods for use thereof | ALEX PHILLIP (US) | 2015-07-21 | — | — | US | disclosed |
| US-20130142869-A1 | Compositions Comprising Non Steroidal Anti-inflammatory Drugs and Methods for Use Thereof | ALEX PHILLIP (US) | 2013-06-06 | — | — | US | disclosed |
| EP-0963752-B1 | Silicone solvents for antiperspirant salts | GEN ELECTRIC (US) | 2006-08-30 | — | — | EP | disclosed |
| EP-1638981-A1 | ALUMINUM/ZIRCONIUM/GLYCINE ANTIPERSPIRANT ACTIVES STABILIZED WITH BETAINE | Colgate-Palmolive Company (US) | 2006-03-29 | — | — | EP | disclosed |
| CN-1241538-C | Antimicrobial compositions containing transition metal chelator salts | UNILEVER NV (NL) | 2006-02-15 | — | — | CN | disclosed |
| WO-2005003142-A1 | ALUMINUM/ZIRCONIUM/GLYCINE ANTIPERSPIRANT ACTIVES STABILIZED WITH BETAINE | COLGATE-PALMOLIVE COMPANY (US) | 2005-01-13 | — | — | WO | disclosed |
| EP-1074577-B1 | Process to produce solutions of antiperspirant salts in silicone solvents | GEN ELECTRIC (US) | 2004-06-02 | — | — | EP | disclosed |
| CN-1395483-A | Anti-microbial compositions comprising salt of transition metal chelator | UNILEVER NV (NL) | 2003-02-05 | — | — | CN | disclosed |
| US-6268519-B1 | DISSOLVING SALT IN WATER OR ORGANIC SOLVENT OR MIXTURE THEREOF TO FORM SOLUTION; ADDING SILICONE FLUID; REMOVING THE WATER OR ORGANIC SOLVENT OR MIXTURE UNDER HEAT, VACUUM TO PROVIDE A CLEAR SOLUTION OF SALT IN SILICONE FLUID | GENERAL ELECTRIC COMPANY | 2001-07-31 | — | — | US | disclosed |
| EP-1074577-A1 | Silicone solvents for antiperspirant salts | GENERAL ELECTRIC COMPANY (US) | 2001-02-07 | — | — | EP | disclosed |
| US-6180121-B1 | FOR DEODORANTS AND ANTIPERSPIRANTS, TO GIVE A DEODORANT EFFECT AGAINST MALODOR FROM UNDERARM PERSPIRATION AND ENHANCE PERFORMANCE OF FRAGRANCE | COLGATE-PALMOLIVE COMPANY | 2001-01-30 | — | — | US | disclosed |
| US-6136302-A | MIXING A ZIRCONIUM SALT AND AN ALUMINUM SALT TO FORM A ZIRCONIUM-ALUMINUM SALT | THE PROCTER & GAMBLE COMPANY (US) | 2000-10-24 | — | — | US | disclosed |
| US-5969172-A | SOLUBILITY/MISCIBILITY, CLARITY | GENERAL ELECTRIC COMPANY (US) | 1999-10-19 | — | — | US | disclosed |
| US-5520907-A | Clear antiperspirant sticks | CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC. (US) | 1996-05-28 | — | — | US | disclosed |
| US-H1473-H | Mixture containing polyhydric alcohol, dibenzyl monosorbitol acetal, and borate salt | CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC. 33 BENEDICT PLACE | 1995-08-01 | — | — | US | disclosed |
| US-5236700-A | Zirconium aluminum glycinate and-or aluminum chlorohydrate | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-08-17 | — | — | US | disclosed |
| US-5185144-A | Administering zirconium aluminum glycinate and/or aluminum chlorohydrate | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-02-09 | — | — | US | disclosed |
| US-4781917-A | FREE OF UNBOUND WATER | THE PROCTOR & GAMBLE COMPANY (US) | 1988-11-01 | — | — | US | disclosed |