Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL3996469 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL3311729 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL5689090 | 0.96 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL3121145 | 0.96 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL2161269 | 0.96 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL5740059 | 0.96 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL9995855 | 0.96 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL700064 | 0.93 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL3028174 | 0.93 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL5472175 | 0.93 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10576308-B2 | Antiperspirant products | THE PROCTER & GAMBLE COMPANY (US) | 2020-03-03 | — | — | US | disclosed |
| US-9795205-B2 | Dispensing package | THE PROCTER & GAMBLE COMPANY (US) | 2017-10-24 | — | — | US | disclosed |
| US-20170281987-A1 | ANTIPERSPIRANT PRODUCTS | PROCTER & GAMBLE (US) | 2017-10-05 | — | — | US | disclosed |
| US-9707416-B2 | Antiperspirant products | THE PROCTER & GAMBLE COMPANY (US) | 2017-07-18 | — | — | US | disclosed |
| EP-2391239-B1 | DISPENSING PACKAGE | PROCTER & GAMBLE (US) | 2015-07-29 | — | — | EP | disclosed |
| US-20130039687-A1 | Dispensing Package | THE PROCTER & GAMBLE COMPANY (US) | 2013-02-14 | — | — | US | disclosed |
| US-20100196299-A1 | Antiperspirant Products | THE PROCTER & GAMBLE COMPANY | 2010-08-05 | — | — | US | disclosed |
| US-20100196079-A1 | Dispensing Package | THE PROCTER & GAMBLE COMPANY | 2010-08-05 | — | — | US | disclosed |
| WO-2010088651-A2 | ANTIPERSPIRANT PRODUCTS | THE PROCTER & GAMBLE COMPANY (US) | 2010-08-05 | — | — | WO | disclosed |
| WO-2010088652-A2 | DISPENSING PACKAGE | THE PROCTER & GAMBLE COMPANY (US) | 2010-08-05 | — | — | WO | disclosed |
| EP-1521568-A1 | NON-IRRITATING ANTIPERSPIRANT COMPOSITIONS CONTAINING ACIDIC ANTIPERSPIRANT ACTIVE | THE PROCTER & GAMBLE COMPANY (US) | 2005-04-13 | — | — | EP | disclosed |
| US-6835373-B2 | A particulate antiperspirant active having a metal to chloride molar ratio of <= to about 1.3, a volatile solvent, a low surface tension nonvolatile solvent and a suspending agent | THE PROCTER & GAMBLE COMPANY | 2004-12-28 | — | — | US | disclosed |
| WO-2004006877-A1 | NON-IRRITATING ANTIPERSPIRANT COMPOSITIONS CONTAINING ACIDIC ANTIPERSPIRANT ACTIVE | THE PROCTER & GAMBLE COMPANY (US) | 2004-01-22 | — | — | WO | disclosed |
| US-20040009133-A1 | Non-irritating antiperspirant compositions containing acidic antiperspirant active | THE PROCTER & GAMBLE COMPANY | 2004-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100196299-A1 | Antiperspirant Products | PPM1G, PSTPIP2, ATP6AP1 | CA4 1251/4885GLRA1 1115/4885SLC6A9 1459/4885 |
| US-20040009133-A1 | Non-irritating antiperspirant compositions containing acidic antiperspirant active | SIGMAR1, PTPN6, PTPN14 | CA4 877/4885GLRA1 767/4885SLC6A9 964/4885 |
| US-20170281987-A1 | ANTIPERSPIRANT PRODUCTS | PPM1G, PSTPIP2, ATP6AP1 | CA4 1251/4885GLRA1 1115/4885SLC6A9 1459/4885 |
| US-10576308-B2 | Antiperspirant products | PPM1G, PSTPIP2, ATP6AP1 | CA4 1251/4885GLRA1 1115/4885SLC6A9 1459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.