Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 4/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 6/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28106186 | 0.76 | PARP10 (0.50) | SYKRPS6KB1FLT3 | |
| SCHEMBL18553767 | 0.76 | SCN9A (0.54) | MAPK10MAPK8LTA4HACVR1TGFBR1 | |
| SCHEMBL2219515 | 0.76 | CTNNB1 (0.50) | MAPK10MAPK8RPS6KB1FLT3AKT1 | |
| SCHEMBL18553807 | 0.74 | LTA4H (0.62) | MAPK10MAPK8LTA4HACVR1SCN9A | |
| SCHEMBL16676723 | 0.73 | BTK (0.48) | MAPK10MAPK8LTA4HSYKSCN9A | |
| Hydrochloric Acid SCHEMBL16670652 | 0.72 | BTK (0.48) | MAPK10MAPK8LTA4HSYKSCN9A | |
| SCHEMBL28227975 | 0.68 | SYK (0.48) | MAPK10MAPK8SYKFLT3 | |
| SCHEMBL25463509 | 0.68 | LTA4H (0.52) | MAPK10MAPK8LTA4HSCN9AFLT3 | |
| SCHEMBL572738 | 0.68 | ACVR1 (0.66) | ACVR1 | |
| SCHEMBL29987229 | 0.67 | BTK (0.70) | MAPK10MAPK8LTA4HSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648464-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINCARBOXAMID DERIVATIVES AND RELATED COMPOUNDS AS T-CELL ACTIVATION INHIBITORS FOR THE TREATMENT OF INFLAMMATIONS | AMGEN INC. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009443-A1 | 2-AMINO-4-HYDROXY-5-PYRIMIDINECARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF T CELL ACTIVATION FOR THE TREATMENT OF INFLAMMATORY DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |