Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 1/20 | 0.65 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.47 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ITGAV | P06756 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7163529 | 0.94 | ITGA4 (0.67) | ITGA4ITGB1ITGA5L3MBTL1GAA | |
| SCHEMBL3860100 | 0.94 | ITGA4 (0.67) | ITGA4ITGB1ITGA5L3MBTL1GAA | |
| SCHEMBL6712483 | 0.91 | ITGA4 (0.57) | ITGA4ITGB1ITGA5L3MBTL1GAA | |
| SCHEMBL7071151 | 0.90 | ITGA4 (0.58) | ITGA4ITGB1ITGA5L3MBTL1GAA | |
| SCHEMBL5690767 | 0.90 | ITGA4 (0.54) | ITGA4ITGB1ITGA5L3MBTL1ITGAV | |
| SCHEMBL7314087 | 0.89 | ITGA4 (0.57) | ITGA4ITGB1ITGA5L3MBTL1GAA | |
| SCHEMBL5690347 | 0.88 | ITGA4 (0.75) | ITGA4ITGB1ITGA5L3MBTL1GAA | |
| SCHEMBL3848814 | 0.88 | ITGA4 (0.53) | ITGA4ITGB1ITGA5GAAHPGD | |
| SCHEMBL3851600 | 0.87 | ITGA4 (0.59) | ITGA4ITGB1ITGA5GAAFKBP1A | |
| SCHEMBL3857921 | 0.87 | ITGA4 (0.54) | ITGA4ITGB1ITGA5GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001974-B1 | 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARM INC (US) | 2006-05-24 | — | — | EP | claimed |
| EP-1001974-B1 | 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARM INC (US) | 2006-05-24 | — | — | EP | disclosed |
| US-6291453-B1 | 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 | ATHENA NEUROSCIENCES, INC. | 2001-09-18 | — | — | US | disclosed |