SCHEMBL5690682

SCHEMBL5690682

COC(=O)[C@H](Cc1cccc(NC(=O)C2CCN(C(=O)OC(C)(C)C)CC2)c1)NC(=O)[C@@H]1CCCN1S(=O)(=O)c1ccc(C)cc1

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 9/20 0.51
HCRTR2 O43614 9/20 0.51
MAPK1 P28482 2/20 0.46
TSHR P16473 1/20 0.46
YAP1 P46937 1/20 0.46
POLB P06746 1/20 0.46
MAPT P10636 1/20 0.46
ITGA4 P13612 1/20 0.45
CYP3A4 P08684 2/20 0.45
ALDH1A1 P00352 1/20 0.45
USP2 O75604 1/20 0.44
CCKBR P32239 1/20 0.44
KDM4E B2RXH2 1/20 0.44
TP53 P04637 1/20 0.44
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5690979 0.94 ALDH1A1 (0.53) HCRTR1HCRTR2MAPK1TSHRYAP1
SCHEMBL5690486 0.91 HCRTR1 (0.54) HCRTR1HCRTR2MAPK1TSHRPOLB
SCHEMBL5690885 0.85 ITGB1 (0.58) MAPK1TSHRITGA4ALDH1A1L3MBTL1
SCHEMBL5692071 0.84 HCRTR1 (0.53) HCRTR1HCRTR2MAPK1TSHRPOLB
SCHEMBL5690951 0.82 KMT2A (0.57) HCRTR1HCRTR2MAPK1TSHRITGA4
SCHEMBL5690698 0.82 MAPK1 (0.53) HCRTR1HCRTR2MAPK1TSHRITGA4
SCHEMBL5690244 0.81 ALDH1A1 (0.56) HCRTR1HCRTR2MAPK1TSHRPOLB
SCHEMBL7071151 0.80 ITGA4 (0.58) MAPK1TSHRITGA4ALDH1A1RAB9A
SCHEMBL5690624 0.80 MAPK1 (0.56) HCRTR1HCRTR2MAPK1TSHRPOLB
SCHEMBL5690712 0.80 ITGB1 (0.56) MAPK1TSHRMAPTITGA4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1001974-B1 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARM INC (US) 2006-05-24 EP claimed
EP-1001974-A1 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-05-24 EP claimed
WO-1999006434-A1 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS INC. (US) 1999-02-11 WO claimed
EP-1001974-B1 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARM INC (US) 2006-05-24 EP disclosed
US-6291453-B1 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 ATHENA NEUROSCIENCES, INC. 2001-09-18 US disclosed
EP-1001974-A1 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-05-24 EP disclosed
WO-1999006434-A1 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS INC. (US) 1999-02-11 WO disclosed