Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5690308 | 1.00 | HDAC8 (0.44) | HDAC8PTPN1NPSR1F10POLB | |
| SCHEMBL5690327 | 0.95 | HDAC8 (0.44) | HDAC8PTPN1NPSR1F10POLB | |
| SCHEMBL6709356 | 0.82 | ALDH1A1 (0.36) | F10MAPTKMT2A | |
| SCHEMBL5690868 | 0.81 | HDAC8 (0.45) | HDAC8PTPN1NPSR1F10POLB | |
| SCHEMBL7421523 | 0.80 | POLB (0.31) | POLBKMT2AMCL1 | |
| SCHEMBL3852759 | 0.79 | P2RX7 (0.37) | NPSR1MEN1KMT2A | |
| SCHEMBL3850225 | 0.77 | P2RX7 (0.32) | — | |
| SCHEMBL6709476 | 0.77 | MAPT (0.46) | PTPN1NPSR1POLBMAPTMEN1 | |
| SCHEMBL7322285 | 0.76 | MAPT (0.36) | MAPTKMT2A | |
| SCHEMBL7316484 | 0.75 | F2 (0.33) | MEN1KMT2AMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001974-B1 | 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARM INC (US) | 2006-05-24 | — | — | EP | claimed |
| EP-1001974-B1 | 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARM INC (US) | 2006-05-24 | — | — | EP | disclosed |
| US-6291453-B1 | 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 | ATHENA NEUROSCIENCES, INC. | 2001-09-18 | — | — | US | disclosed |