Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 8/20 | 0.60 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.56 |
| ▸ | MMP2 | P08253 | 3/20 | 0.54 |
| ▸ | MMP9 | P14780 | 3/20 | 0.54 |
| ▸ | ITGAV | P06756 | 2/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5691183 | 1.00 | ITGB1 (0.60) | ITGB1ITGA5ALDH1A1ITGA4MMP2 | |
| SCHEMBL5690382 | 0.94 | ITGB1 (0.53) | ITGB1ITGA5ALDH1A1ITGA4MMP2 | |
| SCHEMBL6308859 | 0.90 | ALDH1A1 (0.52) | ITGB1ITGA5ALDH1A1ITGA4MMP2 | |
| SCHEMBL5690885 | 0.89 | ITGB1 (0.58) | ITGB1ITGA5ALDH1A1ITGA4ITGAV | |
| SCHEMBL5691859 | 0.88 | ITGB1 (0.64) | ITGB1ITGA5ALDH1A1ITGA4ITGAV | |
| SCHEMBL5690742 | 0.85 | ITGB1 (0.71) | ITGB1ITGA5ALDH1A1ITGA4ITGAV | |
| SCHEMBL5496765 | 0.84 | FKBP1A (0.57) | ITGB1ALDH1A1ITGA4MMP2MMP9 | |
| SCHEMBL5691025 | 0.84 | ITGB1 (0.63) | ITGB1ITGA5ALDH1A1ITGA4ITGAV | |
| SCHEMBL5690712 | 0.84 | ITGB1 (0.56) | ITGB1ITGA5ALDH1A1ITGA4MMP2 | |
| SCHEMBL5690979 | 0.84 | ALDH1A1 (0.53) | ITGB1ITGA5ALDH1A1ITGA4ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001974-B1 | 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARM INC (US) | 2006-05-24 | — | — | EP | claimed |
| US-6291453-B1 | 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 | ATHENA NEUROSCIENCES, INC. | 2001-09-18 | — | — | US | claimed |
| EP-1001974-A1 | 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | Elan Pharmaceuticals, Inc. (US) | 2000-05-24 | — | — | EP | claimed |
| WO-1999006434-A1 | 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS INC. (US) | 1999-02-11 | — | — | WO | claimed |
| EP-1001974-B1 | 4-AMINO-PHENYLALANINE TYPE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARM INC (US) | 2006-05-24 | — | — | EP | disclosed |
| US-6291453-B1 | 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 | ATHENA NEUROSCIENCES, INC. | 2001-09-18 | — | — | US | disclosed |