Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856329 | 1.00 | TRPV1 (0.37) | TRPV1TRPV4SRD5A1ACHEALDH1A1 | |
| SCHEMBL1866161 | 1.00 | TRPV1 (0.37) | TRPV1TRPV4SRD5A1ACHEALDH1A1 | |
| SCHEMBL1855926 | 1.00 | TRPV1 (0.37) | TRPV1TRPV4SRD5A1ACHEALDH1A1 | |
| SCHEMBL20841081 | 0.86 | ACHE (0.44) | ACHEALDH1A1MEN1GAAMAPT | |
| SCHEMBL1859627 | 0.82 | IDH1 (0.34) | TRPV1TRPV4SRD5A1ACHEPNMT | |
| SCHEMBL24452647 | 0.82 | PNMT (0.53) | TRPV1SRD5A1PNMTCYP11B1CYP11B2 | |
| SCHEMBL1863996 | 0.82 | PNMT (0.53) | TRPV1SRD5A1PNMTCYP11B1CYP11B2 | |
| SCHEMBL15086540 | 0.82 | PNMT (0.53) | TRPV1SRD5A1PNMTCYP11B1CYP11B2 | |
| SCHEMBL29495985 | 0.82 | PNMT (0.53) | TRPV1SRD5A1PNMTCYP11B1CYP11B2 | |
| SCHEMBL5469511 | 0.82 | CYP2D6 (0.40) | TRPV1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658269-A1 | FUSED COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | Abbott Laboratories (US) | 2006-05-24 | — | — | EP | disclosed |
| WO-2004111009-A1 | FUSED COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2004-12-23 | — | — | WO | disclosed |