Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | MAOB | P27338 | 2/20 | 0.62 |
| ▸ | APP | P05067 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | BCHE | P06276 | 3/20 | 0.54 |
| ▸ | CASP3 | P42574 | 3/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543861 | 0.86 | MAPT (0.70) | MAPTALDH1A1LMNAHPGDMAOB | |
| SCHEMBL8543868 | 0.86 | MAPT (0.70) | MAPTALDH1A1LMNAHPGDMAOB | |
| SCHEMBL5690297 | 0.82 | XDH (0.62) | MAPTALDH1A1LMNAHPGDMAOB | |
| SCHEMBL5691830 | 0.82 | MAPT (0.73) | MAPTALDH1A1LMNAHPGDMAOB | |
| SCHEMBL8547627 | 0.81 | MAPT (1.00) | MAPTALDH1A1LMNAHPGDMAOB | |
| SCHEMBL8547623 | 0.81 | MAPT (1.00) | MAPTALDH1A1LMNAHPGDMAOB | |
| SCHEMBL5690961 | 0.80 | MAPT (0.76) | MAPTALDH1A1LMNAHPGDACHE | |
| SCHEMBL5690775 | 0.77 | ACHE (0.58) | MAPTALDH1A1LMNAHPGDMAOB | |
| SCHEMBL5690576 | 0.76 | MIF (0.69) | MAPTALDH1A1LMNAHPGDMAOB | |
| SCHEMBL3503220 | 0.75 | MAPT (0.73) | MAPTALDH1A1LMNAHPGDMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1039897-B1 | INADONE AND TETRALONE COMPOUNDS FOR INHIBITING CELL PROLIFERATION | UNIV CALIFORNIA (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6162810-A | Inadone and tetralone compounds for inhibiting cell proliferation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-12-19 | — | — | US | disclosed |